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Clinical Trials/NCT06970691
NCT06970691CompletedNot Applicable

is Generalized Aggressive Periodontitis an Endless Disease When Does it Stop

Rasha Wagih1 site in 1 country92 target enrollmentStarted: January 16, 2020Last updated:
Conditions

Trial Snapshot

Phase
Not Applicable
Status
Completed
Sponsor
Enrollment
92
Locations
1
Primary Endpoint
the radiographic eruption date of the first and the last affected teeth

Study Overview

Brief Summary

Background: Inquiring thoroughly and systematically for evidence supporting the mechanism, time span, onset, or ending events of generalized aggressive periodontitis. The aim of the current retrospective cross-sectional study was to set temporal boundaries of the generalized form of aggressive periodontitis based on eruption time of permanent teeth via panoramic radiographs.

Methods: based on the Egyptian chronology, the primary outcome of the current retrospective study was to assess the correlation between the eruption sequence and the temporal borders of the disease as well as the prevalence of destructive events in accordance to the eruption schedule. The first affected tooth, the last affected tooth, the first unaffected tooth, the number of affected teeth, the presence of interrupted tooth all are factors that extracted from the panoramic radiographs.

Detailed Description

During the last decades, progressive lines of thinking were proposed by generations of brilliant periodontists who tried to describe the aggressive destruction of periodontal tissues. Periodontitis was basically described 2000 years ago but in 18th century, signs and symptoms of periodontitis were firstly recorded.

History of aggressive periodontitis At the beginning of 19th century, alveolar pyorrhea was a term created and explained by two different schools; the European school has described it as a disease which is not affected by local factors while the American school has described local factors especially salivary calculus as the main cause behind alveolar pyorrhea.

Later by the development of histological, radio graphical and microbiological analysis, three other explanation were raised; school of atrophy and degeneration, school of occlusal trauma and school of infection. The European School has supported the theory of atrophy and degeneration especially in young individuals. Their explanation was mainly based on the histological studies which concluded that alveolar bone loss is the primary crucial point in periodontal disease preceded by gingival ulceration and inflammation. Pocket formation and epithelial proliferation are secondary events. Furthermore, they also reported that inflammation and suppuration are strongly connected to the presence of external irritation and entitled it ''Diffuse atrophy''.

Classification of Aggressive periodontitis In 80s and 90s, numerous classifications with various staging and subtypes had been conducted which were not based upon the true diagnostic background. In 1986, the American academy of periodontology acknowledged the exclusion of rapidly progressive periodontitis and added prepubertal periodontitis as a subclass to juvenile periodontitis. In 1989, the American academy classification was modified. They proposed early onset periodontitis to include both prepubertal, juvenile and rapidly progressive periodontitis and added periodontitis associated with systemic disease as separate entity. In 1989, Topic subdivided the periodontal conditions into acute and chronic. The acute condition included periodontal abscess, pericoronitis while the chronic condition included periodontitis (simplex, complex and generalized forms), localized forms (juvenile, post-juvenile and prepubertal) and symptomatic. The latter classification was lacking essential details concerning the periodontal diseases. In 1994, the European Workshop on Periodontology condensed the previous classes into; early onset, adult and necrotizing periodontitis. In 1997, the Committee of American Academy of Periodontology had set a plan to revise the previously proposed classifications.

Sub-typing of aggressive periodontitis Early onset description of periodontitis was mainly based on the influence of patient's age at the time of reporting the evolution of symptoms added to the short-term period in which uppermost destructive events had happened. In 1989 classification, early onset periodontitis was sub-categorized as pre-pubertal juvenile and rapidly progressive periodontitis. Both sub-categories approved to be either localized or generalized.

Study Design

Study Type
Observational
Observational Model
Other
Time Perspective
Cross Sectional

Eligibility Criteria

Ages
18 Years to 60 Years (Adult)
Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • •patients with generalized ggressive perioodntitis only
  • •Panoramic view is a must
  • •Patient age ≥ 18 years
  • •both genders were enrolled
  • •Radiographic evidence of bony defects was compulsory for inclusion.

Exclusion Criteria

  • •patients who did not have panoramic radiograph in their files
  • •Patients less than 18 years are not included

Outcomes

Primary Outcomes

the radiographic eruption date of the first and the last affected teeth

Time Frame: 4 years

based on panoramic view of each patient, the radiographic eruption date of the mentioned teeth was determined.

Secondary Outcomes

  • The radiographic status of the supporting structures of third molars(4 years)

Investigators

Sponsor
Rasha Wagih
Sponsor Class
Other
Responsible Party
Sponsor Investigator
Principal Investigator

Rasha Wagih

Head of periodontology department

Badr University

Study Sites (1)

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