A safety and feasibility study of the capacity of lumbar puncture to reduce elevated intracranial pressure in acute ischaemic stroke.

niversity of Newcastle0 个研究点目标入组 50 人开始时间: 2023年9月6日最近更新: 2024年9月2日

适应症

试验速览

暂无简介。

•1. Patients with acute ischaemic stroke confirmed on clinical and imaging criteria with onset (or time last known to be well) within 24 hours.
•2. Patient’s age is greater than or equal to 18 years of age.
•3. Premorbid mRS is less than or equal to 3.

•1. Patients on anticoagulants and/or taking any antithrombotic agents (e.g., aspirin, clopidogrel). Patients taking any anticoagulant in the last 48 hours or warfarin within the last 5 days at any dose.
•2. Known bleeding diathesis and/or platelet count <100,000.
•3. Patients who have received a thrombolytic agent in the previous 72 hours or are planned to receive a thrombolytic agent.
•4. Intracranial haemorrhage (ICH) or other non-stroke diagnosis to explain the symptoms (e.g., tumour), or any intracranial space-ocupying lesion that could pose a risk of brain herniation identified by baseline imaging.
•5. Basilar artery occlusion or posterior circulation stroke.
•6. Pre-stroke mRS of >2 (indicating significant previous disability).
•7. Any terminal illness such that patient would not be expected to survive more than 1 year.
•8. Any condition that, in the judgement of the investigator could impose hazards to the patients if study therapy is initiated or affect the participation of the patient in the study.
•9. Local skin infection at lumbar puncture site, or known spinal defect likely to impede lumbar puncture, e.g., significant scoliosis.
•10. Patients with cognitive impairment as per treating neurologist.
•11. Clinically evident pregnant women.

发起方

niversity of Newcastle