Vitamin D Supplementation in Critically Ill Children With Respiratory Disease
- Conditions
- Vitamin D Supplementation
- Registration Number
- NCT06547749
- Lead Sponsor
- Assiut University
- Brief Summary
To evaluate the role of vitamin D supplementation in critically ill children with respiratory disease regarding their outcome.
- Detailed Description
Vitamin D is involved in the process of immunomodulation, especially in the context of autoimmunity . Vitamin D has multiple pharmacological effects, such as alleviating the inflammatory response, promoting phagocytosis, and inducing lymphocyte proliferation . previous studies have demonstrated that patients with lower serum vitamin D levels had a longer length of hospital stay and might have an independent relationship with the duration of mechanical ventilation (MV) in critically ill children
.
Approved Vitamin D Supplementation Regimens:
The recommended daily allowance (RDA) or adequate intake (AI) suggested by the Institute of Medicine (IOM) and supported by Health Canada are 400 IU for infants and 600 IU for older children.
Approved High-Dose Regimens:
In addition to RDA, the IOM provides a higher age-specific dose called the tolerable upper intake level (UL), which ranges from 1,000 to 4,000 IU.
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- All
- Target Recruitment
- 40
- All pediatric patients admitted in PICU with respiratory disease with age from 1month to 16 years.
- Patients admitted in PICU due to causes rather than respiratory disease.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Hospital length of stay Baseline How long the patient will stay in Hospital
Ventilator free day Baseline How long is the free days
- Secondary Outcome Measures
Name Time Method