Pilot Study Evaluation of a Combination of Topical 5-Fluorouracil [5FU] and Calcipotriol in the Treatment of Cutaneous Actinic Keratosis [AK] and Intraepidermal Carcinoma [IEC] Lesions

Phase 2

• Conditions: Skin cancer precursors; Skin - Dermatological conditions; Skin - Other skin conditions

• Registration Number: ACTRN12621001242819
• Lead Sponsor: Dr Leith Banney

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2021-09-15
• Last Update Posted: 20 September 2021

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

Adults aged 18-85 years.
Extensive solar damage to skin over the face, as determined by a dermatologist.
Ability to comply with treatment regime as determined by the treating investigator.
Ability to undertake written informed consent prior to initiation of study protocol.
Ability/willing to attend follow up clinic visits that will include clinical photography.
Able to complete study surveys.

Exclusion Criteria

Patients commencing acitretin, other oral or topical retinoids or oral vitamin B3 in the past 3 months and for the duration of the study.
Patients with known allergy/hypersensitivity to 5FU cream.
Patients with known dihydropyrimidine dehydrogenase (DPD enzyme) deficiency.
Patients who are pregnant or breastfeeding. Female participants should avoid pregnancy and breastfeeding during use of treatment cream until three-month review.

Study & Design

• Study Type: Interventional
• Study Design: Not specified