Omics of Cancer: OncoGenomics
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 试验地点
- 1
- 主要终点
- establish a registry in which clinical data of participants with cancer or cancer predisposition is linked to the genomic database of analyzed samples
研究概览
简要总结
Background:
Cancer is a leading cause of death in the United States. Researchers want to know more about how cancer develops and grows. They want to understand more about cancers that run in families. This information will help them find better ways to diagnose and treat cancer. Researchers need to collect data from many people who either have cancer or who may get cancer.
Objective:
To establish a registry of data about people with cancer. The natural history registry will be linked to a database with information about their genetics.
Eligibility:
People aged 4 weeks and older with a diagnosis of any cancer. People with precancerous conditions or with a family history of an inherited cancer are also needed.
Design:
Participants will answer questions about their medical history. This visit can be in-person or by phone.
Participants will provide blood and saliva samples. Researchers will also collect any samples the participants may already have given in the past. These may include tumor biopsies or samples of bone marrow or other body fluids. No blood will be collected from children younger than 3 years.
No new surgeries or biopsies will be done for this study.
The samples will be used for genetic research.
Researchers will follow up with participants once a year. They will get an updated medical history. They will ask for any new biopsies or other tissue samples. They may collect new saliva and blood samples.
Participants may continue in the study for the rest of their lives....
详细描述
Background
- Cancer is the second leading cause of disease-related mortality in the US and the primary leading cause of US disease-related mortality in individuals aged 40-79
- One of the missions of the Oncogenomics Section is to identify new targets and develop new therapeutic strategies for currently incurable malignancies as well as to improve the quality of life for adults and children with cancer. Overall, approximately 1,918,030 individuals, 983,160 males, and 934,870 females will be diagnosed with cancer in 2022
Objective
-To establish a registry in which clinical data of participants with cancer or cancer predisposition is linked to the genomic database of analyzed samples
Eligibility
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 4 Weeks 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
establish a registry in which clinical data of participants with cancer or cancer predisposition is linked to the genomic database of analyzed samples
时间窗: 20 yrs
perform systematic genetic and genomic analysis to enrolled participants treated at the Center for Cancer Research (CCR, NCI) and all Divisions of NCI for the identification of biomarkers and targets of potential therapeutic actionability
次要结局
- determine the feasibility of longitudinal collection and analyses of liquid biopsies alongside the analysis of matched tumor samples(Ongoing throughout study)
- analyze germline samples(Ongoing throughout study)
- examine tumor samples(Ongoing throughout study)