Understand, Plan and Improve Care and Wellbeing of Patients at High Risk of Transfer From Peritoneal Dialysis to Hemodialysis, Epidemiology (Phase 1)
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 17,000
- 试验地点
- 1
- 主要终点
- Incidence of transfer from peritoneal dialysis to hemodialysis
研究概览
简要总结
Transitions from peritoneal dialysis to hemodialysis are common during kidney replacement therapy and may be associated with adverse outcomes. However, the incidence, predictors, and outcomes of PD-to-HD transitions at a national level remain incompletely characterized.
This study will use Canadian dialysis and hospitalization databases to examine the epidemiology and outcomes of PD-to-HD transitions among adults initiating dialysis in Canada. The study will evaluate transition incidence, predictors, and post-transition outcomes including mortality, transplantation, modality changes, and hospitalizations.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adults (≥18 years)
- •Dialysis initiation in Canada between January 1, 2005 and December 31, 2018
- •Peritoneal dialysis duration >30 consecutive days
排除标准
- •Dialysis initiation in Quebec or Manitoba during the study period
- •Dialysis initiation in a foreign country
- •Missing data on initial dialysis modality
- •Pre-emptive kidney transplantation
研究组 & 干预措施
Patient receiving peritoneal dialysis with transfer to hemodialysis
Adults initiating dialysis in Canada between 2005 and 2018 who received peritoneal dialysis and experience a transfer to hemodialysis for 2 or more consecutive days.
结局指标
主要结局
Incidence of transfer from peritoneal dialysis to hemodialysis
时间窗: From PD initiation until 1-year after PD start Also assessed at from PD initation until 2- and 5-year after PD start.
Measured as cumulative incidence and incidence rate of transitions following initiation of PD and censored at time of death, kidney transplantation, transfer home hemodialysis, or administrative end of follow-up.
次要结局
- All-cause mortality after transfer from peritoneal dialysis to hemodialysis(From first day after transfer up to 1-year post transfert. Also assessed ad 2- and 5-year post transfer)
- Return to Peritoneal Dialysis(From first day after transfer to HD up to 180-day post transfer. Also measured at 90- and 365-day post transfer.)
- Transfer to Home Hemodialysis(From first day after transfer to HD until 180-day post transfer. Also measured at 90- and 365-day post transfer)
研究者
Annie-Claire Nadeau-Fredette
Nephrologist, Clinical Scientist
Ciusss de L'Est de l'Île de Montréal