ISRCTN19684749已完成未知
The CELEB trial: Comparative Effectiveness of Lung volume reduction surgery for Emphysema and Bronchoscopic lung volume reduction with valve placement
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 入组人数
- 88
研究概览
简要总结
2018 Protocol article in https://www.ncbi.nlm.nih.gov/pubmed/30337307 protocol (added 30/10/2019) 2023 Results article in https://doi.org/10.1183/13993003.02063-2022 (added 03/05/2023)
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •1. Adults (aged 18 or over) with COPD
- •2. FEV1 <60% predicted
- •3. Significant hyperinflation (TLC>100% predicted, RV>170% predicted)
- •4. Ex-smoker >3 months
- •5. MRC dyspnoea score 3 or more
- •6. CT scan assessed at MDT to have intact interlobar fissures (>90%) and heterogeneous emphysema
- •7. Provision of informed consent to participate
排除标准
- •1. Smoking within 3 months
- •2. CT scan shows interlobar fissures are not intact
- •3. Major comorbidity limiting survival
- •4. Significant pulmonary fibrosis
- •5. FEV1 and TLco <20%
- •6. PaO2 < 7.0kPa
- •7. PaO2 > 7kPa
- •8. Presence of interlobar collateral ventilation assessed by Chartis system
研究者
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