Detection of Hypovolemia in the Elderly Patient Undergoing Surgery
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 143
- 试验地点
- 1
- 主要终点
- Incidence of hypovolemia (%)
研究概览
简要总结
Prospective observational study, in which the primary aim of the study is to determine the incidence of perioperative hypovolemia in the elderly patient scheduled for major surgery. Hypovolemia is defined as the presence of fluid responsiveness, which equals increase in stroke volume > 10% after a passive leg raise according to the Nexfin non-invasive cardiac output measurement.
This study aims to include 150 elderly patients aging 70 years or older undergoing scheduled major surgery. The passive leg raising test on 4 consecutive time points in the perioperative period.
详细描述
Rationale:
There is currently limited evidence available on the occurrence of perioperative hypovolemia in the elderly population, and whether this hypovolemic state is related to postoperative complications in these patients. More information regarding this relationship may be valuable in strategies aiming for a reduction in postoperative complications in the elderly. In particular, postoperative complications lead to long term morbidity, decrease quality of live, increase health care costs and are the most important factor of patient survival. Therefore, the present study aims to investigate how many elderly patients suffer from hypovolemia in the perioperative period, and how this relates to postoperative complications.
Objective:
The primary aim of the study is to determine the incidence of perioperative hypovolemia in the elderly patient scheduled for major surgery. Hypovolemia is defined as the presence of fluid responsiveness, which equals increase in stroke volume > 10% after a passive leg raise according to the Nexfin non-invasive cardiac output measurement.
Study design:
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 70 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Informed consent
- •Age 70 years or older
- •Scheduled for elective surgery
- •Procedures with expected postoperative stay of at least two days
排除标准
- •Procedure in ambulatory practice
- •Acute surgery
- •Patients with current cardiac arrhythmias
- •Symptoms of cardiovascular shock or decompensation at presentation
- •Impossible to perform measurements due to patient characteristics
- •Inability to comprehend patient information and consequences of the study
结局指标
主要结局
Incidence of hypovolemia (%)
时间窗: Preoperatively; and postoperatively (at 2, 24 and 48 hours postoperatively)
preoperative incidence of hypovolemia (stroke volume increase of 10% or more upon a passive leg raising manoeuvre)
次要结局
- Postoperative mortality(30 day)
- Anesthetic technique(intra-operative (duration of surgical procedure))
- Postoperative care(30 day)
- Blood transfusion(intra-operative (duration of surgical procedure))
- Vaso-active therapy(intra-operative (duration of surgical procedure))
- Postoperative complications(30 day)
- Fluid administration(intra-operative (duration of surgical procedure))
- Duration of surgery(intra-operative (duration of surgical procedure))
研究者
Carolien SE Bulte
Principal investigator
Amsterdam UMC, location VUmc