Galantamine in the Treatment of Post-Traumatic Headache
- Conditions
- Post-Traumatic HeadacheHead Trauma,ClosedRetention Disorders,Cognitive
- Registration Number
- NCT00219869
- Lead Sponsor
- Rapoport, Alan, M.D.
- Brief Summary
Most patients with CPTH present with additional major cognitive, behavioral and somatic problems. Most drugs used currently have a negative influence on cognition. Therefore, treatment strategies addressing both the headache and cognitive disturbances in patients with CPTH are necessary. (CPTH; Chronic Post Traumatic Headache).
- Detailed Description
Headache is the most common symptom after a closed head injury, persisting for more then 2 months in 60% of the patients. CPTH is an important cause of consultations in neurology offices and headache clinics, posing a severe burden and affecting the quality of life of sufferers.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 30
Age range 18-75 CPTH according to ICHD-2 Fertile woman using adequate birth control Willing and able to give informed consent Willing and able to complete the entire course of the study to comply with study instructions Stable does of preventive medication
Subject is pregnant or lactating Significant medical or psychiatric disease Previous failure to 4 or more adequate trials of preventive medication Patient on non-stable dose of medication used to prevent CPTH
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method Primary Headache Efficacy Measure; number of pain free days after 3 months
- Secondary Outcome Measures
Name Time Method Consumption of rescue medication Number of days with moderate or severe headache after 3 months.
Trial Locations
- Locations (1)
The New England Center for Headache
🇺🇸Stamford, Connecticut, United States