Combination chemotherapy of hepatic arterial infusion chemotherapy with cisplatin and S-1in patients with advanced hepatocellular carcinoma: phase I trial
Phase 1
- Conditions
- Hepatocellular carcinoma
- Registration Number
- JPRN-UMIN000003113
- Lead Sponsor
- ational Cancer Center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 25
Inclusion Criteria
Not provided
Exclusion Criteria
1) Prior chemotherapy with cisplatin and fluorouracil for hepatocellular carcinoma 2) Prior radiotherapy, transcatheter arterial chemoembolization, and hepatic arterial chemotherapy for portal vein tumor thrombosis of hepatocellular carcinoma 3) Refractory pleural effusion or ascites 4) Distant metastases 5) Allergic reaction to iodine contrast material 6) Severe renal disease 7) Severe heart disease 8) Active infection excluding hepatitis B or C viral infection 9) Active concomitant malignancy 10) Severe mental disorder 11) Severe allergic reaction to drug 12) Pregnant and lactating females; females of childbearing age unless using effective contraception
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Dose limited toxicity
- Secondary Outcome Measures
Name Time Method Response rate Progression free survival Overall survival