Effect of Two Exercise Programs on Bone Strength and Architecture

Not Applicable

Completed

• Conditions: Osteoporosis
• Interventions: Behavioral: Ground Reaction Forces; Behavioral: Joint Reaction Forces

• Registration Number: NCT02636530
• Lead Sponsor: University of Colorado, Denver

Brief Summary

Bone responds according to the load placed on it. In this study, investigators want to know if exercise that loads the body in exercises, like walking or jogging (Ground Reaction Forces: GRF), affects bone differently than exercises that load the joints, like weight lifting (Joint Reaction Forces: JRF). Participants will exercise at least 3 times a week for 6 months. Measures of bone strength and mass, muscular strength, and aerobic fitness will be taken at the beginning and the end of the 6 month program. Period blood samples will be taken for future analysis of blood markers.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2015-12-17
• Study First Submitted QC: 2015-12-18
• Study First Posted: 2015-12-21
• Study Start: 2016-07-01
• Primary Completion: 2021-12-01
• Study Completion: 2021-12-01
• Status Verified: 2022-01
• Last Update Submitted: 2022-01-06
• Last Update Posted: 2022-01-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 48

Inclusion Criteria

• non-smoker
• in generally good health
• not physically active (less than 60 minutes of purposeful exercise/week)
• able to travel to the exercise facility a minimum of 3 times/week

Exclusion Criteria

• use of glucocorticoids
• abnormal resting EKG
• angina and/or evidence of acute myocardial ischemia during a treadmill test
• resting blood pressure above 150 mmHg systolic of 90 mmHg diastolic
• anti-resorptive drug use in the last 2 years
• initiation of treatments that could impact bone metabolism (diuretics, hormones, bine anabolic agents) in the prior 6 months
• dual-energy x-ray absorptiometry (DXA) t-score <+ -2.5 at the femoral neck and/or lumbar spine
• serum vitamin D concentration <20 ng/mL
• uncontrolled thyroid disease
• any contraindications to regular exercise

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Ground Reaction Forces	Ground Reaction Forces	Participants will have an individualized exercise program that includes walking, jogging, stair climbing, and box jumping.
Joint Reaction Forces	Joint Reaction Forces	Participants will have an individualized exercise program that includes weight lifting and aerobic rowing.

Primary Outcome Measures

Name	Time	Method
Change in Volumetric Bone Mineral Density (vBMD)	Baseline and 6 month	Measured via quantitative computed tomography (QCT)
Change in Areal Bone Mineral Density (aBMD)	Baseline and 6 month	Measured via dual-energy x-ray absorptiometry (DXA)
Change in Bone Strength	Baseline and 6 month	Measured via finite element analysis (FEA) from QCT

Secondary Outcome Measures

Name	Time	Method
Change in 1-Repetition Maximum (1RM)	Baseline and 6 month
Change in Maximal Oxygen Uptake (cardiovascular fitness)	Baseline and 6 month

Trial Locations

Locations (2)

University of Colorado Anschutz Medical Campus; 🇺🇸 Aurora, Colorado, United States

Veteran's Affairs Eastern Colorado Healthcare System; 🇺🇸 Denver, Colorado, United States