Postmortem Evaluation of Adrenal and Other Endocrine Tumors in Patients With Sudden Death Without Definitive Causative Diagnosis (PEA-SuddenDeath)
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Primary Aldosteronism
- Sponsor
- Helsinki University Central Hospital
- Enrollment
- 400
- Locations
- 1
- Primary Endpoint
- CYP11B1 staining in adrenal glands
- Status
- Active, not recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
Sudden Cardiac Death is a leading cause of mortality and remains a major public health burden worldwide. Cardiac arrest due to coronary heart disease explains a large proportion of the cases, but if autopsy is not performed the exact underlying cause remains obscure in many adults who face sudden death outside heath care organizations. The investigators aim to find proof that primary aldosteronism is a risk factor for sudden death and to characterize the prevalence of adrenal pathology in sudden death of undetermined cause in a case-control study. In addition, the study aims to characterize the prevalence of other adrenal pathology i.e. silent adenomas, cortisol-producing adenomas and pheochromocytomas in sudden death. The investigators also seek evidence that other endocrine hormone overproduction-causing diseases are more prevalent in persons with sudden death compared with those experiencing traumatic or suicidal death sudden death.
Investigators
Niina Matikainen
M.D., Ph.D, , Assoc. Prof.
Helsinki University Central Hospital
Eligibility Criteria
Inclusion Criteria
- •Consecutive patients with out-of-hospital, sudden death
Exclusion Criteria
- •Estimated time from death to refrigerator more than 24-48 hours and in the refrigerator time more than 7 days (susceptibility to excessive tissue breakdown)
- •Terminal disease
- •Institutionalized patients
Outcomes
Primary Outcomes
CYP11B1 staining in adrenal glands
Time Frame: Through study completion, an average of 2 years
Histopathological diagnosis of the autopsy
CYP11B2 staining in adrenal glands
Time Frame: Through study completion, an average of 2 years
Histopathological diagnosis of the autopsy
Secondary Outcomes
- CYP11B2 staining in adrenal glands(Through study completion, an average of 2 years)
- Pheochromocytoma or paraganglioma(Through study completion, an average of 2 years)
- Neuroendocrine tumor(Through study completion, an average of 2 years)