跳至主要内容
临床试验/NCT05446779
NCT05446779进行中(未招募)不适用

Postmortem Evaluation of Adrenal and Other Endocrine Tumors in Patients With Sudden Death Without Definitive Causative Diagnosis (PEA-SuddenDeath)

Helsinki University Central Hospital1 个研究点 分布在 1 个国家目标入组 400 人开始时间: 2022年2月3日最近更新:
适应症

试验速览

阶段
不适用
状态
进行中(未招募)
入组人数
400
试验地点
1
主要终点
CYP11B1 staining in adrenal glands

研究概览

简要总结

Sudden Cardiac Death is a leading cause of mortality and remains a major public health burden worldwide. Cardiac arrest due to coronary heart disease explains a large proportion of the cases, but if autopsy is not performed the exact underlying cause remains obscure in many adults who face sudden death outside heath care organizations. The investigators aim to find proof that primary aldosteronism is a risk factor for sudden death and to characterize the prevalence of adrenal pathology in sudden death of undetermined cause in a case-control study. In addition, the study aims to characterize the prevalence of other adrenal pathology i.e. silent adenomas, cortisol-producing adenomas and pheochromocytomas in sudden death. The investigators also seek evidence that other endocrine hormone overproduction-causing diseases are more prevalent in persons with sudden death compared with those experiencing traumatic or suicidal death sudden death.

研究设计

研究类型
Observational
观察模型
Case Control
时间视角
Cross Sectional

入排标准

年龄范围
35 Years 至 70 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Consecutive patients with out-of-hospital, sudden death

排除标准

  • Estimated time from death to refrigerator more than 24-48 hours and in the refrigerator time more than 7 days (susceptibility to excessive tissue breakdown)
  • Terminal disease
  • Institutionalized patients

结局指标

主要结局

CYP11B1 staining in adrenal glands

时间窗: Through study completion, an average of 2 years

Histopathological diagnosis of the autopsy

CYP11B2 staining in adrenal glands

时间窗: Through study completion, an average of 2 years

Histopathological diagnosis of the autopsy

次要结局

  • CYP11B2 staining in adrenal glands(Through study completion, an average of 2 years)
  • Pheochromocytoma or paraganglioma(Through study completion, an average of 2 years)
  • Neuroendocrine tumor(Through study completion, an average of 2 years)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Niina Matikainen

M.D., Ph.D, , Assoc. Prof.

Helsinki University Central Hospital

研究点 (1)

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