Postmortem Evaluation of Adrenal and Other Endocrine Tumors in Patients With Sudden Death Without Definitive Causative Diagnosis (PEA-SuddenDeath)
试验速览
- 阶段
- 不适用
- 状态
- 进行中(未招募)
- 入组人数
- 400
- 试验地点
- 1
- 主要终点
- CYP11B1 staining in adrenal glands
研究概览
简要总结
Sudden Cardiac Death is a leading cause of mortality and remains a major public health burden worldwide. Cardiac arrest due to coronary heart disease explains a large proportion of the cases, but if autopsy is not performed the exact underlying cause remains obscure in many adults who face sudden death outside heath care organizations. The investigators aim to find proof that primary aldosteronism is a risk factor for sudden death and to characterize the prevalence of adrenal pathology in sudden death of undetermined cause in a case-control study. In addition, the study aims to characterize the prevalence of other adrenal pathology i.e. silent adenomas, cortisol-producing adenomas and pheochromocytomas in sudden death. The investigators also seek evidence that other endocrine hormone overproduction-causing diseases are more prevalent in persons with sudden death compared with those experiencing traumatic or suicidal death sudden death.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 35 Years 至 70 Years(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Consecutive patients with out-of-hospital, sudden death
排除标准
- •Estimated time from death to refrigerator more than 24-48 hours and in the refrigerator time more than 7 days (susceptibility to excessive tissue breakdown)
- •Terminal disease
- •Institutionalized patients
结局指标
主要结局
CYP11B1 staining in adrenal glands
时间窗: Through study completion, an average of 2 years
Histopathological diagnosis of the autopsy
CYP11B2 staining in adrenal glands
时间窗: Through study completion, an average of 2 years
Histopathological diagnosis of the autopsy
次要结局
- CYP11B2 staining in adrenal glands(Through study completion, an average of 2 years)
- Pheochromocytoma or paraganglioma(Through study completion, an average of 2 years)
- Neuroendocrine tumor(Through study completion, an average of 2 years)
研究者
Niina Matikainen
M.D., Ph.D, , Assoc. Prof.
Helsinki University Central Hospital
