Preoperative CRT using IMRT for LARC

Phase 1

• Conditions: ocally advanced rectal cancer

• Registration Number: JPRN-jRCTs051180039
• Lead Sponsor: Mizowaki Takashi

Brief Summary

Preoperative chemoradiotherapy using IMRT for this population might alleviate acute gastrointestinal toxicity, achieving high LRC and sphincter preservation.

Detailed Description

Not available

Study Timeline

• Study Start: 2019-01-30
• Study Completion: 2021-01-17
• Results First Posted: 2021-11-23
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 12

Inclusion Criteria

1) Histologically confirmed adenocarcionma
2) Resectable rectal cancer
i) clinically T3-4 and N0-2
ii) Ra or Rb
iii) Inferior margin of tumor is located below the peritoneal reflection
3) No hepatic, peritoneal metastasis
4) 20-80 years
5) Performance Status: 0-2
6) No previous treatment
7) Adequate organ function
8) Able to take drugs orally
9) Written informed consent

Exclusion Criteria

1) Active other synchronous cancer
2) Receiving flucytosin or atazonavi
3) Suffering the active infection
4) Uncontrollable comorbidity
5) Pregnant or breastfeeding women,
6) Reciving steroid medication
7) Difficult to join due to mental disorder

Study & Design

• Study Type: Interventional
• Study Design: Not specified