Relationship between local control rate and overall survival rate in stereotactic body radiotherapy for early-stage lung cancer: systematic review
- Conditions
- on-small cell lung cancer
- Registration Number
- JPRN-UMIN000046913
- Lead Sponsor
- Ofuna Chuo Hospital
- Brief Summary
Purpose: Local control (LC) is an important outcome of local cancer therapy, besides overall survival (OS). We conducted a comprehensive literature search to investigate whether a high LC rate contributes to good OS in radiotherapy for early-stage non-small cell lung cancer (ES-NSCLC). Conclusions: Three-year LC was correlated with three-year OS in patients receiving radiotherapy for ES-NSCLC. A 5% increase in 3-year LC is expected to improve the 3-year CSS and OS rates by 3.8% and 2.8%, respectively.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 13435
Not provided
Articles including metastasis or articles which overall survival and local control rates are not determined on a one-to-one basis will be excluded. Studies involving patients with metastatic lung tumors, postoperative recurrence or lymph node metastases, or studies restricted to elderly patients are excluded. The reports were excluded if patients are recruited for a certain property of the tumor or patients characteristics such as pathology, ground-glass opacity, operability, or interstitial pneumonia. Data that only reported outcomes for specific patient groups (e.g., operable vs. inoperable) or tumor groups (e.g., histologically proven vs. unproven) and for which no overall outcome was given are excluded. Studies including particle therapy and concurrent chemotherapy are excluded. Concurrent chemotherapy is not permitted.
Study & Design
- Study Type
- Others,meta-analysis etc
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Meta-regression analysis to investigate correlation coefficient between local control and overall survival
- Secondary Outcome Measures
Name Time Method Meta-regression analysis to investigate correlation coefficient between local control and outcomes including cancer-specific survival, distant metastases-free survival, and disease-free survival