Japanese Alzheimer's Disease Neuroimaging Initiative, Second Stage

Recruitment & Eligibility

Status: Complete: follow-up complete

Sex: All

Target Recruitment: 500

Inclusion Criteria

Not provided

Exclusion Criteria

1. Parkinson' disease, Lewy body dementia, frontotemporal dementia, Huntington's disease, progressive supranuclear palsy or other neurodegenerative diseases other than AD. Multiple cerebral infarction, normal pressure hydrocephalus, brain tumor, epilepsy, subdural hematoma, multiple sclerosis, head trauma with sequelae will also be excluded. 2. Signs of brain infection, focal brain lesions (eg infarction) that may affect cognitive function. Individuals with subcortical small infarction or diffuse white matter lesions can be included except for those in specific lesions affecting cognition. Cortical infarcts are normally excluded. 3. Presence of pacemaker, arterial clip, artificial valves, artificial cochlea, and other magnetic/electroconductive metals in the body that may affect MRI scan. 4. Major depression or bipolar disorder within past 1 year, past history of schizophrenia, defined by DSM-IV. 5. Addiction to alcohol or other drugs within past 2 years. 6. Past history of psychiatric symptoms, agitation or abnormal behaviors that affect protocol adherence within past 3 months. 7. Presence of fatal or unstable diseases. 8. Vitamin B12 or folate deficiency, syphilis, thyroid function abnormality. 9. Admission to care home or hospitals. 10. Administration of specific drugs (defined in J-ADNI2 procedure manual) including psychoactive drugs and warfarin. 11. Administration of any drugs in clinical trial within 1 month prior to screening. 12. Participation in clinical studies or clinical trials other than J-ADNI.

Study & Design

Study Type: Observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method

Secondary Outcome Measures

Name	Time	Method

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