Relationships between genetic variability and plasma donepezil levels in Thai patients with dementia

Not Applicable

Completed

• Conditions: Dementia; Donepezil; CYP2D6

• Registration Number: TCTR20190924003
• Lead Sponsor: Faculty of Medicine, Chulalongkorn Unviersity

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2019-04-01
• Study Start: 2019-09-24
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

Thai dementia patients during the maintenance phase of treatment with cholinesterase inhibitor (donepezil) were enrolled from the Dementia Outpatient Clinic, King Chulalongkorn Memorial Hospital, Bangkok, Thailand.

Exclusion Criteria

Patients who were not treated with donepezil.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Relationship of CYP2D6 genotype or phenotypes to plasma donepezil concentration 2 year Univariate and multivariate analysis

Secondary Outcome Measures

Name	Time	Method
CYP2D6 allle frequency in dementia patients 2 year Descriptive statistics