JPRN-UMIN000005394已完成4 期
Effect of Active Vitamin D Treatment on Sarcopenia Incidence Among Adults with Prediabetes - Randomized Controlled Trial- - DPVD ancillary trial
niversity of Occupational and Environmental Health Kokura Medical Association, Health Testing Center Fujisawa City Hospital Shin Komonji Hospital0 个研究点目标入组 1,256 人开始时间: 2011年4月7日最近更新:
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 1,256
研究概览
简要总结
During a median follow-up of 2.9 years, 79 (12.5%) of 630 participants in the eldecalcitol group and 89 (14.2%) of 626 in the placebo group developed type 2 diabetes (HR 0.87, 95%CI 0.67 to 1.17, P=0.39). After adjustment for confounding factors by multivariable fractional polynomial Cox regression analysis, eldecalcitol significantly lowered the development of diabetes (HR 0.69, 0.51 to 0.95, P=0.020).
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 30years-old 至 90years-old（—）
- 性别
- All
入选标准
- 未提供
排除标准
- •1. Individuals who have participated in other clinical trials. 2. Individuals who have been treated with active vitamin D, vitamin D supplement, and/or calcium preparation within the preceding 3-month period. 3. Individuals who have already been diagnosed with type 1, type 2 diabetes, and/or sarcopenia. 4. Individuals in whom drug treatment for prediabetes has been initiated. 5. Individuals who are pregnant or have severe diseases, such as renal insufficiency (serum creatinine of 1.5 mg/dl or higher), hepatic insufficiency, psychosis, collagen diseases, heart diseases, and cerebrovascular diseases. 6. A sub investigator may preclude participant involvement in the study based on screening and assessment of the participants condition.
研究者
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