The Effects of Prebiotics on Behavioral and Biological Markers of Cognition and Stress
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Physiological Stress
- Sponsor
- University of Illinois at Urbana-Champaign
- Enrollment
- 24
- Locations
- 1
- Primary Endpoint
- Biological markers of stress
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
This research intervention aims to examine the effects of prebiotic consumption on changes in behavioral and biological measures of cognition and stress among adults.
Detailed Description
Evidence-based dietary strategies provide behavioral means benefiting physical and cognitive function. Pertinent to the proposed work, dietary intake has been recently shown to have the potential to directly influence the gut microbiota composition as well as brain function. Specifically, the consumption of prebiotics or fibers metabolized by gut bacteria may also play a role. These foods are readily available in the marketplace, however, their implications for physical and cognitive function are not clear. Accordingly, the proposed study aims to investigate effects of prebiotic beverage consumption on changes in behavioral and biological measures of cognition and stress among adults.
Investigators
Hannah Holscher
Assistant Professor of Nutrition
University of Illinois at Urbana-Champaign
Eligibility Criteria
Inclusion Criteria
- •Males and females
- •Between the ages of 25-45 years at the time of consent
- •BMI ≥18.5 kg/m2
- •Normal or corrected-to-normal vision based on the minimal 20/20 standard in order to complete the cognitive task.
- •Ability to drop-off fecal sample within 15 minutes of defecation
Exclusion Criteria
- •Current pregnancy or lactation
- •Tobacco use
- •Dairy allergy or intolerance
- •Prior diagnosis of metabolic and gastrointestinal disease (cardiovascular disease and type 1 or type 2 diabetes, chronic constipation, diarrhea, Crohn's disease, celiac disease, ulcerative colitis, irritable bowel syndrome, diverticulosis, stomach or duodenal ulcers, hepatitis, HIV, cancer, etc.)
- •Prior diagnosis of cognitive or physical disability, including ADHD, severe asthma, epilepsy, chronic kidney disease
- •Use of any anti-psychotic, anti-depressant, antianxiety, or ADD/ADHD medications
- •Use of medications that alter normal bowel function and metabolism (e.g., recent antibiotic use, laxatives, enemas, anti-diarrheal agents, narcotics, antispasmodics, diuretics, anticonvulsants).
- •Prior malabsorptive bariatric surgery (i.e. gastric bypass, sleeve gastrectomy) or restrictive bariatric surgery (i.e. adjustable gastric band)
Outcomes
Primary Outcomes
Biological markers of stress
Time Frame: 4-5 weeks
Changes in 24-hour urinary cortisol, inflammatory markers (e.g. IL-6, CRP).
Behavioral markers of stress
Time Frame: 4-5 weeks
Change in reported questionnaire responses specific to depression, stress, and anxiety using the Depression, Anxiety, and Stress (DASS) Questionnaire.
Secondary Outcomes
- Gastrointestinal Microbiota composition(4-5 weeks)
- Cognitive function(4-5 weeks)
- Gastrointestinal Microbiota alpha-diversity(4-5 weeks)
- Gastrointestinal microbiota beta-diversity(4-5 weeks)
- Sleep(4-5 weeks)