Medical Follow-up of New Cases of Polyarthritis in Children and Young Adults

Recruiting

• Conditions: Juvenile Idiopathic Arthritis; Rheumatoid Arthritis; Diffuse Systemic Sclerosis; Seronegative Arthritis; Psoriatic Arthritis; Systemic Lupus Erythematosus

• Registration Number: NCT07000916
• Lead Sponsor: Université Catholique de Louvain

Brief Summary

Population:

Juvenile idiopathic arthritis (JIA), rheumatoid arthritis (RA) and seronegative / psoriatic / undifferentiated arthritis (UA), systemic lupus erythematosus (SLE) or diffuse systemic sclerosis dSS).

Naïve to basic treatment OR treated for ≤ 3 months; except for patients with JIA.

These 5 cohorts will be subject to standardized clinical monitoring.

Detailed Description

This study is proposed by the Rheumatology and Pediatrics departments of the 3 French-speaking Universities.

The first objective will be to include a progressive number of new young patients (≤ 50 years) in order to optimize and standardize care and clinical response objectives. The number of 25% of new incident cases will be sought with an increase of 20% each year during the 5 to 10 years of this project.

Population: JIA, RA/UA, SLE, dSS (American Congres of Rheumatology criteria). Naïve to basic treatment OR treated for ≤ 3 months; except for patients with JIA.

These 5 cohorts will be subject to standardized clinical monitoring and specific objectives that will make it possible to analyze the number of patients with a good control of the disease and/or a clinical remission, defined according to the international criteria.

Study Timeline

• Study Start: 2013-09-11
• Study First Submitted: 2019-04-25
• Status Verified: 2025-05
• Study First Submitted QC: 2025-05-22
• Last Update Submitted: 2025-05-22
• Study First Posted: 2025-06-03
• Last Update Posted: 2025-06-03
• Primary Completion: 2028-03-31
• Study Completion: 2028-03-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 1000

Inclusion Criteria

• Diagnosis of juvenile idiopathic arthritis, rheumatoid arthritis and seronegative / psoriatic / undifferentiated arthritis, systemic lupus erythematosus or diffuse systemic sclerosis (ACR criteria).
• Naïve to basic treatment OR treated for ≤ 3 months; except for patients with JIA.

Exclusion Criteria

• Treated for > 3 months
• > 50 years old

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Remission rate or absence of synovitis in Rheumatoid arthritis patients	Through the entire study, during approximately 15 years

Trial Locations

Locations (1)

UCLouvain; 🇧🇪 Brussels, Belgium