Disconnection and Unilateral Spatial Neglect

Completed

• Conditions: Stroke
• Interventions: Other: Cognitive assessment

• Registration Number: NCT05268159
• Lead Sponsor: University Hospital, Lille

Brief Summary

Retrospective cohort study of consecutive patients investigated in a neurorehabilitation ward after a first hemispheric stroke. Unilateral spatial Neglect (USN) and other cognitive impairments (including attention, executive functions, memory) have been assessed in routine care at the subacute phase (\<6 months). MRI scans have also been done in routine care.

The study aims at linking lesion characteristics, disconnections induced and expression of the different modalities of USN

Detailed Description

Not available

Study Timeline

• Study Start: 2011-06-01
• Primary Completion: 2021-12-31
• Study Completion: 2021-12-31
• Status Verified: 2022-02
• Study First Submitted: 2022-02-24
• Study First Submitted QC: 2022-03-04
• Study First Posted: 2022-03-07
• Last Update Submitted: 2022-05-17
• Last Update Posted: 2022-05-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 300

Inclusion Criteria

• First hemispheric adult stroke patient
• Non-opposed to inclusion
• Confirmed by MRI
• Assessment of cognitive functions during the subacute phase (3 weeks to 6 months after stroke onset

Exclusion Criteria

• History of previous stroke or neurological disorders
• Inability to perform cognitive assessment due to severe comprehension, cognitive or psychiatric disorder
• Uncorrected severe loss of visual acuity
• Contra-indications to MRI

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Stroke patients	Cognitive assessment	Stroke patients admitted to the Lille Neurological rehabilitation unit after a first-ever hemispheric stroke, assessed at the subacute phase (\< 6months)

Primary Outcome Measures

Name	Time	Method
Assessment of peripersonal Unilateral Neglect with the BEN (Batterie d'évaluation de la negligence, Battery of tests for the quantitative assessment of unilateral neglect)	One assessment, during the subacute phase after stroke (3 weeks to 6 months)

Secondary Outcome Measures

Name	Time	Method
Assessment of Executive Functions with the Trail Making Test	One assessment, during the subacute phase after stroke (3 weeks to 6 months)
Assessment of Executive Function with Verbal and Categorial Fluency test	One assessment, during the subacute phase after stroke (3 weeks to 6 months)
Assessment of verbal Memory with the verbal span task	One assessment, during the subacute phase after stroke (3 weeks to 6 months)
Assessment of personal Unilateral Spatial Neglect with the Fluff Test	One assessment, during the subacute phase after stroke (3 weeks to 6 months)
Assessment of personal Unilateral Spatial Neglect with the Comb and Razor Test	One assessment, during the subacute phase after stroke (3 weeks to 6 months)
Assessment of Attention with the Test of Attentional Performance	One assessment, during the subacute phase after stroke (3 weeks to 6 months)
Assessment of Executive Functions with the Stroop Test	One assessment, during the subacute phase after stroke (3 weeks to 6 months)
Gait assessment (Lindmark score)	3 months after stroke
Assessment of Executive Functions with the test of commissions	One assessment, during the subacute phase after stroke (3 weeks to 6 months)
Assessment of verbal Memory with the Grober and Buschke Task	One assessment, during the subacute phase after stroke (3 weeks to 6 months)
Assessment of visual Memory with the Doors test	One assessment, during the subacute phase after stroke (3 weeks to 6 months)
Assessment of visual Memory with the Rey figure test	One assessment, during the subacute phase after stroke (3 weeks to 6 months)
Identification of brain lesions by Anatomical MRI (T1, FLAIR, T2*, Diffusion)	up to 6 months
Postural assessment with the PASS	3 months after stroke

Trial Locations

Locations (1)

Hop Swynghedauw; 🇫🇷 Lille, France