JPRN-jRCT2031230438招募中1 期
A Phase 1 Study to Evaluate the Safety and Tolerability, Pharmacokinetics,Pharmacodynamics, and Antitumor Activity of GEN1042 Monotherapy and in Combination With Pembrolizumab +- Chemotherapy in Japanese Subjects With Malignant Solid Tumors
ozaki Akira0 个研究点目标入组 30 人开始时间: 2023年11月7日最近更新:
试验速览
- 阶段
- 1 期
- 状态
- 招募中
- 发起方
- 入组人数
- 30
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- >= 18age old 至 ot applicable（—）
- 性别
- All
入选标准
- •Have measurable disease according to RECIST v1.1.
- •- Must have an Eastern Cooperative Oncology Group (ECOG) performance status (PS) score of 0-1.
- •- Must have acceptable organ and bone marrow function.
- •- Have a life expectancy of at least 3 months.
排除标准
- •- Has clinically significant toxicities from previous anticancer therapies.
- •- Has rapidly progressing disease.
- •- Has a history of noninfectious pneumonitis/interstitial lung disease.
- •- Has a history of liver disease.
- •- Has had an allogeneic tissue/solid organ transplant or autologous or allogeneic bone marrow transplant, or stem cell rescue within 3 months prior to the first dose of GEN1042.
- •- Has any history of intracerebral arteriovenous malformation, cerebral aneurysm, or progressive brain metastases or stroke.
- •- Has had major surgery within 4 weeks before Screening.
研究者
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