Pharmacological Treatment in Osteoarthritis
- Conditions
- Osteoarthritis of the handMedDRA version: 12.1Level: LLTClassification code 10019115Term: Hand osteoarthritis
- Registration Number
- EUCTR2010-019684-11-NL
- Lead Sponsor
- Maasstad Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Authorised-recruitment may be ongoing or finished
- Sex
- All
- Target Recruitment
- Not specified
Age = 40 years
Primary hand OA according to the ACR classification
Heberden or Bouchard nodule or Kellgren-Lawrence grade 1, 2 or 3 in = 2 symptomatic joints
Pain in the dominant hand = 12 months
Use of an NSAID for = 1 episode of pain
Written informed consent
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range
F.1.3 Elderly (>=65 years) yes
F.1.3.1 Number of subjects for this age range
Secondary hand OA, e.g. hemochromatose, rheumatoid arthritis, posttraumatic
Kellgren-Lawrence grade 4 OA
Use of hydroxychloroquine within 3 months before entering the study
Use of NSAIDs or corticosteroids within 7 days before entering the study
Retinopathy
Known allergy or hypersensitivity for hydroxychloroquine
Study & Design
- Study Type
- Interventional clinical trial of medicinal product
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Main Objective: To evaluate the efficacy of hydroxychloroquine 400 mg QD in hand osteoarthritis;Secondary Objective: none;Primary end point(s): Pain intensity at week 24 measured on a 100 mm Visual Analogue scale
- Secondary Outcome Measures
Name Time Method