Feasibility of fNIRS guided Neurofeedback training in Parkinson’s disease patients

Not Applicable

• Conditions: G20; Parkinson disease

• Registration Number: DRKS00022997
• Lead Sponsor: eurokognition und Funktionelle Neurorehabilitation Abteilung für Neuropsychologie Department für Psychologie Carl von Ossietzky Universität Oldenburg

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2020-10-02
• Study Completion: 2022-01-24
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 64

Inclusion Criteria

Diagnosis of Parkinson's Disease according to UK PD Society Brain Bank Criteria (Hughes et al., 1992) within a Hoehn & Yahr stadium of 1 –3

Exclusion Criteria

All:
- any affection of the central nervous system
- psychological and psychiatric diseases
- cognitive impairment as measured by the MoCa (Cut-off of 25 points)
- less than 4 hours of sleep

Parkinson's Patients:
- stable medication all along the study duration
- Dementia at a PANDA cut-off value of 18 points (Kalbe et al., 2008)

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Primary outcome is to measure with fNIRS the increase/decrease of oxygenated/deoxygenated hemoglobin concentration changes of the SMA over the four training sessions. It is expected that the SMA activity is increased post-training as compared to pre-training measurements.<br>The concentration changes of healthy elderly subjects and of the Parkinson's disease patients will be compared. Furthermore, a comparison of healthy elderly participants receiving neurofeedback and the group of healthy elderly subjects not receiving neurofeedback will be conducted.

Secondary Outcome Measures

Name	Time	Method
As a secondary measure the electromyogram (EMG) of the upper limbs will be measured. It will be investigated whether the EMG changes over the training sessions and afterwards; furthermore, it will be explored whether these changes differ between the patient group and the groups of healthy elderly participants (with and without neurofeedback).