Public health emergency SOLIDARITY trial of treatments for COVID-19 infection in hospitalized patients
- Conditions
- COVID-19 (SARS-CoV-2 infection)Infections and Infestations
- Registration Number
- ISRCTN83971151
- Lead Sponsor
- World Health Organization
- Brief Summary
2020 Interim results article in https://doi.org/10.1101/2020.10.15.20209817 interim results in preprint (added 19/10/2020) 2021 Results article in https://pubmed.ncbi.nlm.nih.gov/33264556/ interim results for remdesivir, hydroxychloroquine, lopinavir and interferon (added 25/03/2021) 2022 Results article in https://pubmed.ncbi.nlm.nih.gov/35512728/ final results and updated meta-analyses (added 06/05/2022)
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 11266
1. Adults (aged =18 years) hospitalized with definite COVID-19
2. Not already receiving any of the study drugs
3. Without known allergy or contraindications to any of them (in the view of the physician responsible for their care)
4. Without anticipated transfer within 72 h to a non-study hospital
Patients invited to join the study will be those who are admitted to a collaborating hospital; no wider recruitment efforts are expected
Current exclusion criteria as of 21/04/2020:
1. Any of the available study drugs are contra-indicated (e.g. because of patient characteristics, chronic liver or heart disease, or some concurrent medication)
2. Declined to participate in the study
Previous exclusion criteria:
1. Any of the available study drugs are contra-indicated (e.g. because of patient characteristics, chronic liver or heart disease, or some concurrent medication)
2. Pregnant
3. Declined to participate in the study
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method All-cause mortality, subdivided by the severity of disease at the time of randomization, measured using patient records throughout the study
- Secondary Outcome Measures
Name Time Method <br> Measured using patient records:<br> 1. Duration of hospital stay (hours)<br> 2. Time to first receiving ventilation (or intensive care) (hours)<br>