Classification and Comparison of Early-onset and Late-onset Idiopathic Chronic Pancreatitis
试验速览
- 阶段
- 不适用
- 入组人数
- 1,633
- 试验地点
- 1
- 主要终点
- Basic characteristics of early-onset idiopathic chronic pancreatitis and late-onset idiopathic chronic pancreatitis
研究概览
简要总结
Classification of early-onset idiopathic chronic pancreatitis (EOICP) and late-onset idiopathic chronic pancreatitis (LOICP) was proposed based on bimodal distribution of age at onset of idiopathic chronic pancreatitis (ICP). However, studies of larger populations prove it may be normal distribution. Therefore, the aim of the study is to find what the distribution of age at onset of ICP is and whether the classification of EOICP and LOICP is meaningful.
详细描述
Idiopathic chronic pancreatitis (ICP) patients admitted to the investigator's center from January 2000 to December 2013 were enrolled. Characteristics were compared between early-onset idiopathic chronic pancreatitis (EOICP) and late-onset idiopathic chronic pancreatitis (LOICP) patients. Cumulative rates of diabetes mellitus, steatorrhea, pancreatic stone, pancreatic pseudocyst (PPC), biliary stricture, and pancreatic cancer after the onset and the diagnosis of ICP were calculated, respectively. Different cut-off values for age at onset of ICP were set to classify EOICP and LOICP. Then differences of clinical courses between EOICP and LOICP were compared when classified by distinct cut-off values.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients diagnosed with idiopathic chronic pancreatitis according to Asia-Pacific consensus
排除标准
- •Pancreatic cancer diagnosed within 2 years after the diagnosis of chronic pancreatitis
- •Groove pancreatitis
- •Autoimmune pancreatitis
- •Chronic pancreatic patients with identified etiologies
结局指标
主要结局
Basic characteristics of early-onset idiopathic chronic pancreatitis and late-onset idiopathic chronic pancreatitis
时间窗: December 31, 2013
Identify respective ratio of patients with male gender and patients with smoking history in early-onset idiopathic chronic pancreatitis and late-onset idiopathic chronic pancreatitis in traditional classification (traditional classification: age at onset of idiopathic chronic pancreatitis\<35 years old as early-onset idiopathic chronic pancreatitis; age at onset of idiopathic chronic pancreatitis\>35 years old as late-onset idiopathic chronic pancreatitis).
Distribution of age at onset of idiopathic chronic pancreatitis
时间窗: December 31, 2013
Identify the distribution of age at onset of idiopathic chronic pancreatitis.
次要结局
- Diabetes mellitus(August 31, 2019)
- Pancreatic cancer(August 31, 2019)
- Steatorrhea(August 31, 2019)
- Common bile duct stricture(August 31, 2019)
- Pancreatic pseudocyst(August 31, 2019)
- Basic characteristics of early-onset idiopathic chronic pancreatitis and late-onset idiopathic chronic pancreatitis with different cut-off values for age at onset of idiopathic chronic pancreatitis(August 31, 2019)
研究者
Zhaoshen Li
Director of Gastroenterology Department
Changhai Hospital