NCT00515476已完成不适用
Randomized, Clinical Trial to Study the Effect of Exercise Training on the Function of HDL-Cholesterol, Endothelial Function, Oxidative Stress and Regenerative Capacity of Endothelial Progenitor Cells in Patients With Metabolic Syndrome
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 24
- 试验地点
- 2
- 主要终点
- Primary: vasculoprotective and regenerative functions of HDL-Cholesterol and EPC function before and after 8-weeks exercise training
研究概览
简要总结
The purpose of the present study is to characterize the quality of HDL-Cholesterol in patients with metabolic syndrome and reduced blood HDL-Cholesterol levels and to examine the effect of exercise training on the vasculoprotective effects of HDL-Cholesterol in these patients. Additionally the investigators aim to investigate the endothelial function, oxidative stress and the regenerative capacity of the endothelial progenitor cells in patients with metabolic syndrome and the changes dependent on physical activity of patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 21 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Reduced HDL-Cholesterol levels in blood: < 40 mg/dl (1.03 mmol/L) in male, < 50 mg/dl (1.29 mmol/L) in female
- •Plus two of the following criteria:
- •Elevated waist circumference: ≥ 102 cm (≥ 40 inches) in men or ≥ 88 cm (≥ 35 inches) in women
- •Elevated triglycerides: ≥ 150 mg/dL (1.7 mmol/L
- •Elevated blood pressure: ≥ 130 mmHg systolic blood pressure or ≥ 80 mmHg
- •diastolic blood pressure or anti-hypertensive treatment
- •Elevated fasting glucose: ≥ 100 mg/dL or on drug treatment for elevated fasting glucose
排除标准
- •Acute coronary syndrome
- •Unstable Angina pectoris
- •Myocardial infarction during the last 8 weeks
- •Therapy with Niacin
- •Active infections
- •Ventricular arrhythmias
- •Systolic blood pressure > 160 mmHg or diastolic blood pressure > 95 mmHg
- •Pregnancy, lactation
- •Alcoholism
结局指标
主要结局
Primary: vasculoprotective and regenerative functions of HDL-Cholesterol and EPC function before and after 8-weeks exercise training
时间窗: before and after 8-weeks exercise training
次要结局
- Secondary: flow-mediated, endothelium-dependent vasodilation of radial artery measured by ultrasound(before and 8 weeks after exercise training)
研究者
研究点 (2)
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