Polynucleotides for facial skin rejuvenation comparing between sharp and cannula techniques
- Conditions
- To study the effectiveness of polynucleotides on the cheek area To assess the side effects and safety between the sharp needle and blunt cannula injection techniques.Polynucleotides, facial pores, pore size, skin quality
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 30
1.Aged between 18 to 50 years
2.In good health with no serious chronic illnesses
3.Has enlarged pores on both cheeks equally
4.Able to attend scheduled appointments and comply with the research protocol
5.Willing to participate in the research by signing the consent form
History or suspicion of infection at the lesion site
Uncontrolled inflammatory acne vulgaris
History of keloid scars or hypertrophic scars
Immunocompromised condition
History of skin cancer
History of herpes infection
History of taking vitamin A derivatives in the past 3 months
History of receiving treatment on the cheeks with laser, dermabrasion, chemical peeling, radiofrequency, or focused ultrasound in the past 3 months
Injection of fillers in the cheek area within the past 6 months
History of diabetes
History of connective tissue disorders
History of allergy to anesthetics
Pregnant or breastfeeding women
Refusal or request to withdraw from the study
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Pore volume, pore index week 0, 4, 8, 12, 16, and 20 Antera 3D, Visia skin analysis, Criteria of visual assessment for pore
- Secondary Outcome Measures
Name Time Method Side effects week 0, 4, 8, 12, 16, and 20 Subjective evaluation,Sebum level week 0, 4, 8, 12, 16, and 20 Sebumeter,Moisture week 0, 4, 8, 12, 16, and 20 MoistureMeter by Delfin,Skin redness week 0, 4, 8, 12, 16, and 20 Antera 3D,Visia skin analysis,Skin roughness week 0, 4, 8, 12, 16, and 20 Antera 3D, Visia skin analysis,Skin pigmentation week 0, 4, 8, 12, 16, and 20 Antera 3D, Visia skin analysis