The Efficacy of Native Kidney Biopsy by Cranial versus Caudal Direction.
- Conditions
- Active kidney disease that need further investigation by kidney biopsy.kidney biopsycephalic directioncaudal direction
- Registration Number
- TCTR20170706001
- Lead Sponsor
- Research Facilitation Division, Faculty of Medicine Vajira Hospital.
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 120
Participant is sent for kidney biopsy due to indication:
glomerulonephritis
nephrotic syndrome
rapidly progressive glomerulonephritis
unexplained cause of acute kidney injury
unexplained cause of proteinuria
follow up after treatment
1. Serum creatinine > 3.5 mg/dL (duration > 3 months)
2. Kidney size by ultrasound is below than 8 centimeters in length, 3.5 centimeters in width or cortex thickness below 0.8 centimeters.
3. Prothrombin time (PT) > 13.5 seconds,activated partial thromboplastin time (aPTT) > 40 seconds or international normalization ratio (INR) ≥ 1.5
4. Platelet ≤ 100,000/uL
5. Current medication: Aspirin, clopidogrel, warfarin, heparin, LMWH, direct thrombin inhibitor
6. concomitant disease: acquired or congenital platelet dysfunction, bleeding disorder.
ึ7. Kidney transplant status.
8. systolic blood pressure > 160 mmHg or diastolic blood pressure >110 mmHg
9. Body Mass Index > 35 kg/m2
10.Pregnant
11.Active infection (7 days)
12.skin and soft tissue infection locate at biopsy area.
13.Single kidney participant
14.Hemoglobin < 8 g/dL
15.Structural abnormality of kidney
16.un-cooporate participant
17. deny consent
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method number of glomeruli immediately pathology reports
- Secondary Outcome Measures
Name Time Method adequacy of kidney tissue. immediately pathology report,complication (hematuria, perinephric hematoma and obstructive uropathy) 24 hours ultrasound evaluation and clinical evaluation