Chemoradiation for irresectable (T4) oesophageal cancer: a phase II multicentre study

Phase 2

Completed

• Conditions: Oesophageal cancer; Cancer

• Registration Number: ISRCTN15521056
• Lead Sponsor: Erasmus Medical Centre (The Netherlands)

Brief Summary

2006 Results article in https://doi.org/10.1038/sj.bjc.6603134 (added 26/08/2021)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2007-01-01
• Study Start: 2007-02-27
• Last Update Posted: 7 September 2021

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 54

Inclusion Criteria

1. T4 N0-1 M0
2. Tumour length less than 10 cm
3. Upper tumour border 2 cm of upper oesophageal sphincter
4. Tumour must not extend more than 4 cm into the stomach
5. World Health Organisation (WHO) grade zero to two
6. Adequate haematological, renal, hepatic and pulmonal function
7. Adequate caloric- and/or fluid intake

Exclusion Criteria

1. Previous chemotherapy and or radiotherapy on mediastinum or upper abdomen
2. Myocardial Infarction (MI) within last six months
3. Ventricular arrhythmia or congestive heart failure
4. Second or third degree heart blocks
5. Pre-existing neurotoxicity more than grade one
6. Active infection

Study & Design

• Study Type: Interventional
• Study Design: Not specified