Changes in Myocardial Perfusion During Chronic Multi Site Biventricular Versus Right Ventricular Apex Pacing in Patients With Normal Left Ventricular Function Undergoing His Bundle Ablation for Drug-refractory Atrial Fibrillation

Not Applicable

Terminated

• Conditions: Atrial Fibrillation

• Registration Number: NCT00528307
• Lead Sponsor: R&D Cardiologie

Brief Summary

To determine whether Biventricular pacing in patients undergoing HIS bundle ablation for atrial fibrilation has beneficial effects on myocardial perfusion and left ventricularr ejection fraction.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2007-09-11
• Study First Submitted QC: 2007-09-11
• Study First Posted: 2007-09-12
• Study Start: 2007-10
• Primary Completion: 2010-07
• Study Completion: 2010-12
• Status Verified: 2014-11
• Last Update Submitted: 2014-11-04
• Last Update Posted: 2014-11-05

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 5

Inclusion Criteria

• Normal to nearly normal LVF (EF > 40%)
• Drug-refractory, persistent or permanent atrial fibrillation
• Referred for His ablation

Exclusion Criteria

• Unwilling or unable to sign the informed consent
• Life expectancy < 1year from non-cardiac causes
• Previous myocardial infarction
• Previous coronary bypass surgery
• Poor left ventricle function (EF< 40%) from any cause
• Symptomatic obstructive coronary artery disease
• Poor ultra sound imaging quality.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
Difference in size of myocardial perfusion abnormalities in the two treatment groups as measured with MPS.	6 months

Trial Locations

Locations (1)

St Antonius Hospital; 🇳🇱 Nieuwegein, Utrecht, Netherlands