Healthy aging through internet counseling in the elderly: a European, multi-centre, investigator initiated, open-label blinded endpoint (PROBE), parallel group, randomised controlled trial

Academic Medical Centre Amsterdam (Netherlands)0 个研究点目标入组 2,724 人开始时间: 2014年9月5日最近更新: 2022年4月19日

适应症

试验速览

2016 Protocol article in http://www.ncbi.nlm.nih.gov/pubmed/27288376 protocol 2018 Results article in http://www.ncbi.nlm.nih.gov/pubmed/29358447 qualitative sub-study results 2019 Results article in https://pubmed.ncbi.nlm.nih.gov/31175194/ qualitative sub-study results (added 02/06/2020) 2020 Results article in https://pubmed.ncbi.nlm.nih.gov/32764085/ qualitative study results (added 10/08/2020) 2019 Results article in https://pubmed.ncbi.nlm.nih.gov/33323224/ results (added 17/12/2020) 2021 Other publications in https://pubmed.ncbi.nlm.nih.gov/35385395/ Factors predicting engagement in the intervention (added 07/04/2022)

•1. Age = 65 years
•2. Available informant
•3. = 2 cardiovascular risk factors and/or manifest cardiovascular disease defined as:
•3.1. Cardiovascular risk factors:
•3.1.1. Hypertension, defined by any of the following:
•3.1.1.1. Diagnosis by specialist or GP
•3.1.1.2. Currently on anti-hypertensive drugs
•3.1.1.3. Baseline BP: if < 80 years: = 140/90 mmHg; if = 80 years: Systolic BP = 160
•3.1.2. Dyslipidemia, defined by any of the following:
•3.1.2.1. Diagnosis of dyslipidemia by specialist or GP
•3.1.2.2. Use of lipid-lowering drug (this will include persons who have no dyslipidemia, but use it after a previous cardiovascular disease; this is acceptable, since these people automatically fulfil inclusion criteria as well)
•3.1.2.3. Baseline total cholesterol = 5 mmol/L and/or LDL = 2.5 mmol/L
•3.1.3. Overweight, defined by any of the following:
•3.1.3.1. BMI = 30
•3.1.3.2. Waist circumference men =102 cm, women =88 cm
•3.1.4. Active smoking (self-reported, any tobacco use)
•3.1.5. Lack of physical exercise (self-reported) defined as below the WHO norm of 30 minutes 5 times a week (or a total of 150 minutes per week) of intermediate exercise
•3.2. History of cardiovascular disease:
•3.2.1. Stroke/transient ischemic attack (TIA)
•3.2.2. Myocardial infarction
•3.2.3. Angina pectoris
•3.2.4. Peripheral arterial disease
•3.2.5. Diabetes mellitus (DM)

•1. Previously diagnosed dementia as diagnosed by a GP or specialist
•2. Mini Mental State Examination score <24
•3. Any condition expected to limit 18-months compliance and follow-up
•4. Computer illiteracy, defined as unable to send an email and/or do a simple Google search
•5. Severe visual impairment interfering with operating a computer
•6. Participating in another randomised controlled trial

发起方

Academic Medical Centre Amsterdam (Netherlands)