OPTIMIZATION of ADVANCED MR SEQUENCES

Recruiting

• Conditions: MRI; Mental Disorders; Brain Tumor; Neurosciences; Stroke

• Registration Number: NCT05618990
• Lead Sponsor: Centre Hospitalier St Anne

Brief Summary

This monocentric methodological study aims at optimizing advanced MR sequences for image quality (reduced artefacts, signal to noise ratio, acquisition time, stability of quantitative measurements) on a new MR unit dedicated to research in clinical and cognitive neuroscience.

Detailed Description

Primary goal : Optimization of MR protocols and validation of acquisition parameters of advanced MR sequences on healthy volunteers or patients on a new 3T MR unit dedicated to research in neurosciences.

Secondary goals

1. Perform acquisitions to validate the feasibility of research MR protocols (pilot subjects)

2. reproducibility studies

Study Timeline

• Study Start: 2019-11-05
• Study First Submitted: 2022-11-08
• Study First Submitted QC: 2022-11-15
• Study First Posted: 2022-11-16
• Status Verified: 2024-07
• Last Update Submitted: 2024-07-09
• Last Update Posted: 2024-07-10
• Primary Completion: 2025-11-05
• Study Completion: 2025-12-05

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 300

Inclusion Criteria

• 18 ans
• Covered by social security
• For women in age of procreation, under efficient contraception
• Written consent

Exclusion Criteria

• Any MR contraindication
• Claustrophobia
• Pregnancy
• Under judiciary protection

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
MR sequences optimization	72 months	Optimization of MR protocols and validation of acquisition parameters of advanced MR sequences on healthy volunteers or patients on a new 3T MR unit dedicated to research in neurosciences. Outcome measures depend on each pulse optimized sequence (signal-to-noise ratio, contrast-to-noise ratio, quantitative MR biomarkers).

Secondary Outcome Measures

Name	Time	Method
Reproducibility studies	72 months	Reproducibility studies (quantitative parameters, effect of denoising ...). Outcome measures depend on each pulse optimized sequence (artifacts, signal-to-noise ratio, contrast-to-noise ratio, quantitative MR biomarkers).
Pilot studies	72 months	Feasibility studies in cognitive neurosciences. Outcome measures depend on each MR protocol (artifacts, signal-to-noise ratio, contrast-to-noise ratio, quantitative MR biomarkers).

Trial Locations

Locations (1)

OPPENHEIM Catherine; 🇫🇷 Paris, France