A Comparative Study on Efficacy of High Flow Nasal Cannula Oxygen Therapy versus Conventional Oxygen Therapy in Patients Undergoing Bronchoscopy for Bronchoalveolar Lavage : A Randomized Control Trial
Overview
- Phase
- Phase 3
- Status
- Not yet recruiting
- Sponsor
- Pondicherry Institute of Medical sciences.
- Enrollment
- 102
- Locations
- 1
- Primary Endpoint
- To compare the episode of incidence of hypoxia (Spo-90%), between HFNC and COT during bronchoscopy with bronchoalveolar lavage.
Overview
Brief Summary
After obtaining ethical committee clearance of Pondicherry Institute of Medical Sciences, study will be done.
It is randomized control study with study population of 102 participants. After obtaining informed and written consent patient will be randomized into two groups by computer generated randomization. Group A, procedure will be done with Convention oxygen therapy with nasal cannula with 1-15l/min , and titrated according to saturation.
Group B, HFNC will be used and patient oxygen flow rate and FiO 2 will be tapered according to the saturation.
Both group vitals , Saturation, heart rate, respiratory rate, blood pressure will be monitored pre, inter and post procedure.
And patient tolerance, comfort and post procedure adverse events will be monitored for 24 hours post procedure.
Any episodes of desaturated , frequency of interupptions, post procedure complications will be monitored.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Masking
- Participant Blinded
Eligibility Criteria
- Ages
- 18.00 Year(s) to 65.00 Year(s) (—)
- Sex
- All
Inclusion Criteria
- •All patients age 18 years and above with indications of bronchoscopy for bronchoalveolar lavage.
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
To compare the episode of incidence of hypoxia (Spo-90%), between HFNC and COT during bronchoscopy with bronchoalveolar lavage.
Time Frame: Pre procedural (Baseline) | Room air Saturation, Heart Rate. | During procedure-At bronchoscopy insertion, mid-procedure(every 5 minutes), at maximum point of saturation if any | At completion of bronchoscopy. | Immediate Post procedure | Early recovery - 30 mins after procedure. | 1 hour post procedure
Secondary Outcomes
- To compare the patient comfort and tolerance levels between two group , to compare the rate of procedure interruptions due to desaturation, to analyze the post bronchoscopy complications in both group.(It is assessed from the start of procedure to 24 hours post procedure.)
Investigators
G SARIGA
Pondicherry institute of medical sciences