No Prognostic or Molecular Disparity Between Synchronous and Metachronous Metastases in Differentiated Thyroid Cancer: Insight From Middle Eastern Cohort

Completed

• Conditions: Differentiated Thyroid Cancer

• Registration Number: NCT07115810
• Lead Sponsor: King Faisal Specialist Hospital & Research Center

Brief Summary

The goal of this observational study is to compare the clinical outcomes, molecular features, and immune profiles of patients with synchronous and metachronous distant metastases in Saudi cohort with well characterized differentiated thyroid cancer. The main question it aims to answer is whether timing of metastasis is associated with distinct prognostic or biological behavior in differentiated thyroid cancer from a large Middle Eastern cohort

Detailed Description

Not available

Study Timeline

• Primary Completion: 2018-12-31
• Study Completion: 2024-12-31
• Status Verified: 2025-08
• Study First Submitted: 2025-08-04
• Study First Submitted QC: 2025-08-04
• Last Update Submitted: 2025-08-04
• Study First Posted: 2025-08-11
• Last Update Posted: 2025-08-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 178

Inclusion Criteria

• Synchronous or metachronous distant metastases

Exclusion Criteria

• Not DTC
• No distant metastases

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Overall survival	5 years

Secondary Outcome Measures

Name	Time	Method
Thyroid cancer-specific survival	5 years