Efficacy of medium cut-off membrane hemodialysis on middle molecule uremic toxins reduction as comparable with mixed-dilution online HDF : Prospective cross-over study
Phase 4
Recruiting
- Conditions
- End stage renal diseaseHemodialysis,Hemodiafiltration,Mixed dilution HDF,HDF,medium cut off membrane
- Registration Number
- TCTR20201219001
- Lead Sponsor
- The Kidney Foundation of Thailand
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 14
Inclusion Criteria
1.Thai ESRD patient 18-90 year
2.Hemodialysis at KCMH 3/weeks
3.Hemodialysis 3/weeks with Kt/V >/= 1.2
4.Residual renal function < 100ml/day
5.Using AVF or AVG with blood flow rate >/= 400 ml/min
6.Optimal dry weight
7.Hemodynamic stable at least 2 weeks before enrollment
Exclusion Criteria
1.Severe infection
2.Severe CVD
3.Advanced stage malignancy
4.Advanced stage cirrhosis CTP B to C
5.Malnutrition
6.Pregnancy
7.Hemodynamic instability < 2 weeks before enrollment
8.Contraindication for anticoagulants
9.Deny informed consent
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Rate of ß2-microglobulin reduction 8 weeks percentage
- Secondary Outcome Measures
Name Time Method Rate of other middle molecules uremic toxin reduction 8 weeks percentage,Albumin loss in dialysate 8 weeks grams