Inflammatory Biomarkers and Endothelial Function Assessed by Venous Occlusion Plethysmography and Nailfold Videocapillaroscopy in Patients With Resistant Hypertension, Stages 1 and 2 and Normotensive
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 75
- 主要终点
- Blood Pressure (mmHg)
研究概览
简要总结
Nailfold videocapillaroscopy (NVC), Venous occlusion Plethysmography (VOP) and inflammatory biomarkers have been used to study endothelial function in patients with resistant hypertension, stages 1 and 2 hypertension and normotensive. This was a cross-sectional study.
详细描述
Microcirculation determines peripheral resistance contributing to increased blood pressure. The nailfold videocapillaroscopy (NVC), Venous occlusion Plethysmography (VOP) and biomarkers can be used to evaluate the microcirculation in arterial hypertension (AH). The objective of this study is to analyze the behavior of serum inflammatory markers and study the microcirculation by nailfold videocapillaroscopy (NVC) and Venous Occlusion Plethysmography in patients with resistant hypertension (RH), with stages 1 and 2 hypertension (MMH ) and normotensive (CG). A cross-sectional study with 75 patients has been performed: 25 with resistant hypertension (RH), 25 with stages 1 and 2 hypertension (MMH) and 25 normotensive (CG). All underwent anamnesis, dosage serum markers and conducting NVC, VOP. Hypertensive patients without statin use and with controlled or uncontrolled blood pressure were also analyzed. For the statistical analysis were used: Kruskal -Wallis ANOVA, Dunn test and ANCOVA for correction of confusion factors such as age and BMI.
研究设计
- 研究类型
- Observational
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 27 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Clinical diagnosis of controlled High Blood Pressure stages 1 and 2 (blood pressure levels from 140/90 mmHg to 179/109 mmHg) .
- •Resistant Hypertension (uncontrolled hypertension, with values ≥140/90 mmHg, using three or more antihypertensive drugs of different classes, including a diuretic, or controlled hypertension with four or more drugs).
- •Normal Blood Pressure.
排除标准
- •Diabetes Mellitus, Types 1 or
- •Heart Failure.
- •Myocardial infarction or stroke with less than three months of the event.
- •Chronic kidney disease.
- •Use of hormonal or non-hormonal anti-inflammatory drugs.
- •Recent trauma (less than three months).
- •Autoimmune diseases.
- •Infectious processes in activity.
- •Neoplasia.
- •Aspirin use (anti-inflammatory dose).
- •Obesity grade III (Body Mass Index>40 kg/m2).
结局指标
主要结局
Blood Pressure (mmHg)
时间窗: 1 day
Hemodynamic Variable
次要结局
- Functional Capillary Density (FCD, number capillaries/mm2 )(1 day)
- Apical Capillary Diameter (micrometer)(1 day)
- Afferent Capillary Diameter (micrometer)(1 day)
- Efferent Capillary Diameter (micrometer)(1 day)
- Maximal Forearm Blood Flow after sublingual nitroglycerine(1 day)
- Intercellular Adhesion Molecule (ICAM, ng/dl)(up to 2 weeks)
- Time to reach Maximum Red Blood Cell Velocity (s)(1 day)
- Maximal Forearm Blood Flow during reactive Hyperemia(1 day)
- Endothelin (pg/dl)(up to 2 weeks)
- Waist circumference (cm)(1 day)
- Hip circumference (cm)(1 day)
- Vascular Cell Adhesion Molecule (VCAM, ng/dl)(up to 2 weeks)
- Adiponectin (ng/dl)(up to 2 weeks)
- C Reactive Protein (CRP, mg/dl)(up to 2 weeks)
- Red Blood Cell Velocity (mm/s)(1 day)
- Maximum Red Blood Cell Velocity (mm/s)(1 day)
- Body Mass Index (Kg/m2)(1 day)
- Waist to Hip Ratio(1 day)
研究者
Daniel Alexandre Bottino
M.D., PhD
Rio de Janeiro State University