Cardiac Radioablation for VT

Not Applicable

Not yet recruiting

• Conditions: Ventricular Tachycardia; Myocardial Infarction

• Registration Number: NCT06593418
• Lead Sponsor: William Beaumont Hospitals

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2024-9-9
• Last Update Posted: 23 September 2024

Recruitment & Eligibility

• Status: Not yet recruiting
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

Inclusion Criteria:<br><br> - Participants must be 18 years or older.<br><br> - Automatic implanted cardiac defibrillator present.<br><br> - VT is monomorphic with at least two episodes of VT within an eight week (56 day)<br> period as recorded by an AICD or heart failure related to VT or VT storm.<br><br> - Ejection fraction =20%.<br><br> - At least one previous cardiac ablation for VT.<br><br> - VT refractory despite antiarrhythmic medications.<br><br> - Likely to live for 12 months in the absence of VT.<br><br> - AICD in a position in the chest RT to be given without direct radiation.<br><br> - Woman of reproductive age must ensure that she won't become pregnant or breastfeed<br> at the time of RT.<br><br> - The participant has no contraindications to a Cardiac MRI as per routine Cardiology<br> practice.<br><br>Exclusion Criteria:<br><br> - Class IV heart failure<br><br> - Abandoned leads.<br><br> - Prior radiation therapy to the chest or upper abdomen.<br><br> - Interstitial lung disease.

Exclusion Criteria

Not provided

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in number of ventricular tachycardia (VT) episodes from pre-cardiac radioablation to post-cardiac radioablation;Dose limiting toxicity

Secondary Outcome Measures

Name	Time	Method
Efficacy of ablation using target volume definition with Delayed Enhancement Cardiac MRI (DE-CMR)