Cerebral oxygenation during changes in vascular resistance and flow in patients on cardiopulmonary bypass

Completed

• Conditions: Physiology of brain perfusion.; Nervous System Diseases

• Registration Number: ISRCTN17891643
• Lead Sponsor: Academic Medical Center AMC

Brief Summary

2017 results in: https://www.ncbi.nlm.nih.gov/pubmed/27747866 [added 18/01/2019]

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2013-06-14
• Study Start: 2015-10-22
• Last Update Posted: 11 February 2019

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

1. Age 18-70 years
2. Patients scheduled for elective cardiac surgery (CABG, aortic valve repair, mitral valve repair or combinations of the former), using mil hypothermic cardiopulmonary bypass.
3. Written informed consent present

Exclusion Criteria

1. Age =18 years
2. Emergency operations
3. Brain pathology in history (CVA)
4. Severe carotid artery stenosis (if no data is available, an echo-Doppler will be performed by the anesthesiologist after induction of anesthesia, prior to surgery)
5. Severe COPD
6. Absent informed consent
7. SaO2<90% at room temperature
8. Diabetes
9. Kidney failure

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Cerebral oxygenation before and after each intervention.

Secondary Outcome Measures

Name	Time	Method
Arterial blood pressure before and after each intervention.