Predictive Value of Biomarkers on Volemia, Extra and Intra Vascular Varation and Hydroelectrolytic Disorders in Different ICU Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 66
- 试验地点
- 2
- 主要终点
- Predictive value of biomarkers changes in Volemia variation
研究概览
简要总结
The purpose of this study is to determine whether the Biomarkers (pro adrenomedullin (MR proADM), pro arginin vasopressin (CT proAVP), pro atrial natriuretic peptid (MR proANP), Pro Endothelin) changes at Day 2, Day 5 and Day 7 of ICU admission are correlated with Intravascular volume assessed by Cr 51 on red blood cells (Day 2 and Day 7) and by I 125 on albumine Day 7. The correlation of these Biomarkers are also evaluted with other markers such as erythropoietin and catecholamines. 80 ICU patients are included.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •20 Cerebral Hemorrhage
- •20 Head Injury
- •20 post surgery non traumatic non neuro
- •20 Polytrauma patients
排除标准
- •Heart failure NYHA III or IV
- •Renal insufficiency creatinin clearance < 30 ml/mn
- •age < 18 Y
- •Pregnancy
结局指标
主要结局
Predictive value of biomarkers changes in Volemia variation
时间窗: at Day 2, Day 5 and Day 7 of ICU admission
Correlation with total blood volume(assessed by Cr 51) and biomarkers(Mr proADM, Mr proANP, CT proAVP and proendothelin)changes
次要结局
- Predictive value of biomarkers changes with efficient volemia, fluid managements and other Markers such erythropoietin(at Day 2, Day 5 and Day 7 of ICU admission)
- Predictive value of Biomarkers with APACHE II and SOFA score and Prognosis at ICU discharge(at Day 2 , Day 5 and Day 7 of ICU admission and at discharge)