Team-based Interventional Triage in Acute Coronary Syndrome Based on Non-Invasive Computed Tomography Coronary Angiography - a Randomized Trial
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 2,300
- 试验地点
- 7
- 主要终点
- Number of participants with a combined endpoint of major adverse cardiac events
研究概览
简要总结
Coronary computed tomography angiography (CCTA) is a widely accepted initial diagnostic test for individuals suspected of having chronic coronary syndromes. However, there is limited evidence supporting its use in the acute setting. So far, no large-scale randomized trial has examined the performance of CCTA as an alternative to invasive coronary angiography (ICA) in individuals with non-ST-segment elevation myocardial infarction (NSTEACS).
If CCTA were to replace ICA as a routine procedure for individuals with NSTEACS, it could reduce the risk of complications related to ICA, improve patient comfort, expedite decision-making, and reduce healthcare expenses and interhospital transfers.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Number of participants with a combined endpoint of major adverse cardiac events
时间窗: At 1 year.
All-cause mortality, non-fatal myocardial infarction, hospitalization with refractory angina, or hospitalization with heart failure.
次要结局
- Number of participants with a the individual composites of the primary outcome(At 1 year.)
- Number of participants with cardiovascular death(At 1 year.)
- Number of participants with unplanned coronary revascularization(At 1 year.)
- Health-related Quality of life(At 1 year.)
- Angina symptom burden(At 1 year.)
- Total (cumulative) radiation dosage during index admission(At 1st hospital discharge, an average of 2 days.)
- Length of index hospitalization(At 1st hospital discharge, an average of 2 days.)
研究者
Niels Thue Olsen
Associate Professor
Rigshospitalet, Denmark