The observational study on efficacy of oral anticoagulants for cognitive dysfunctions of the patients after cerebral infarction in super-aged society
Not Applicable
- Conditions
- non-valvular atrial fibrillation (NVAF)
- Registration Number
- JPRN-UMIN000026912
- Lead Sponsor
- Okayama University Hospital, Department of Neurology
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- 160
Inclusion Criteria
Not provided
Exclusion Criteria
1) valvular atrial fibrillation 2) CDR>0.5 or MMSE<24 3) the patients after cerebral infarction (under 6 months after the onset) 4) Parkinson disease, Huntington disease, normal pressure hydrocephalus, brain tumor, progressive supranuclear palsy, corticobasal degeneration, multiple system atrophy, epilepsy, subdural hematoma, encephalitis/meningitis, multiple sclerosis, or cognitive decline by head trauma 5) depression, schizophrenia, alcoholism, drug dependence, or other critical disease 6) deficiency of vitamin B1, B12, or folic acid, syphilis, or hypothyroidism 7) difficult to perform the neuropsychological examination 8) other inappropriate state assessed by the researchers
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method the change of MMSE (mini-mental state examination) score between baseline and after 2 years of the registration
- Secondary Outcome Measures
Name Time Method 1) occurrences of death from any cause, dementia, stroke, and cardiovascular events 2) the change of CDR score 3) the change of MoCA score 4) occurrences of hemorrhagic events 5) occurrences of ischemic events