Intensive Care Unit (ICU)-Acquired Colonization and Infection Related to Multidrug Resistant Bacteria (MDR) in Immunocompromised Patients
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Immunocompromised Host
- Sponsor
- University Hospital, Lille
- Enrollment
- 759
- Locations
- 7
- Primary Endpoint
- Density rate of ICU-acquired infections related to MDR in immunosuppressed patients.
- Status
- Completed
- Last Updated
- 3 years ago
Overview
Brief Summary
the number of immunocompromised patients hospitalized in the intensive care units (ICU) is increasing. They are at higher risk of colonization and/or infection with multi-resistant bacteria (MDR). However this risk is not well characterized. ICU acquired infections related to MDR are associated with increased morbidity and mortality. The aim of this study is to compare the incidence of ICU-acquired colonization and ICU-acquired infection related to MDR between immunocompromized and immunocompetent patients. The risk factors for ICU-acquired colonization and ICU-acquired infections, and their impact on outcome will also be evaluated and compared between immunocompromised and immunocompetent patients.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Expected ICU stay \> 48 hours
- •All patients (immunocompromised or immunocompetent).
Exclusion Criteria
- •Patients aged \< 18 years
- •Refusal to take part in the study
- •ICU-stay \< 48 hours
- •Non availability of initial MDR or subsequent screening
- •Participation in another study that could interfere with the risk of ICU-acquired colonization and infection with MDR bacteria
Outcomes
Primary Outcomes
Density rate of ICU-acquired infections related to MDR in immunosuppressed patients.
Time Frame: From ICU admission until day 28 after ICU admission
the number ICU-acquired infections related to MDR will be devided by the number of days in the ICU and reported for 1000 days.
Secondary Outcomes
- Mechanical ventilation duration(From ICU admission until day 28 after ICU admission)
- Density rate of ICU-acquired colonizations related to MDR in immunosuppressed patients(From ICU admission until day 28 after ICU admission)
- Rate of ICU-acquired colonizations related to MDR in immunosuppressed patients.(From ICU admission until day 28 after ICU admission)
- 28 day mortality(from ICU admission until day 28 after admission)
- Rate of ICU-acquired infections related to MDR in immunosuppressed patients(From ICU admission until day 28 after ICU admission)
- length of stay in intensive care unit(From ICU admission until day 28 after ICU admission)