Protective Effects of Exercise Training
- Conditions
- Sleep Deprivation
- Interventions
- Other: Sleep deprivation
- Registration Number
- NCT02820649
- Lead Sponsor
- Institut de Recherche Biomedicale des Armees
- Brief Summary
Rationale. Sleep loss is a risk factor for cardiovascular events mediated through endothelial dysfunction.
Objective. To determine if 7 weeks of exercise training can limit cardiovascular dysfunction induced by total sleep deprivation (TSD) in healthy young men.
Methods: 16 subjects will be examined during 40-h TSD, both before and after 7 weeks of interval exercise training. Vasodilatation induced by ACh, insulin and heat (42°C) as well as pulse wave velocity (PWV), blood pressure and heart rate (HR) will be assessed at baseline, during TSD, and after one night of sleep recovery. Biomarkers of endothelial activation, inflammation, and hormones will bemeasured from morning blood samples at 07:00
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 16
- Healthy
- Men
- 18 - 35 yrs
- Consumming 400 mg of caffeine per day,
- Body mass index (BMI) greater than 30 kg/m²,
- Taking medication.
- Excessive daytime somnolence (Epworth Sleepiness Scale >9)
- Sleep complaints (Pittsburgh Sleep Quality Index >5)
- Inability to be considered as an intermediate chronotype on the Horne and Ostberg questionnaire (score <31 or >69)
- Traines subject (Ricci Gagnon questionnaire >35)
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Exercise training Sleep deprivation 7 weeks of exercise training Control Sleep deprivation Sedentary group
- Primary Outcome Measures
Name Time Method ACh induced Vasodilation during TSD Up to 09:00 during sleep deprivation (i.e. after 26 hours of wakefulness) Cutaneous vasodilation (in % Baseline) induced by local application of Acethylcholine
- Secondary Outcome Measures
Name Time Method Insuline Vasodilation Up to 09:00 during the sleep deprivation day and the recovery day Cutaneous vasodilation (in % Baseline) induced by local application of insulin
blood pressure Every 3 hours during the 40 hours of wakefullness (i.e. total sleep deprivation) Mean, systolic and diastolic blood pressure
Heat vasodilation Up to 9:00 during the sleep deprivation day and during the recovery day Cutaneous vasodilation (in % Baseline) induced by local application of heat (42°C)
Inflammation Up to 7:00 during the sleep deprivation day and during the recovery day. Plasma levels of inflammatory marquers (TNF-alpha, IL1beta...)
PWV Up to 09:00 during the sleep deprivation day Pulse wave velovity evaluated by echography