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临床试验/NCT06208592
NCT06208592已完成不适用

Comparative Study of Sedative Requirement Using Sevoflurane With Anaconda Device Versus Conventional Sedation in Patients With COVID-19

Hospital Español de Mexico1 个研究点 分布在 1 个国家目标入组 43 人开始时间: 2020年5月30日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
43
试验地点
1
主要终点
Intravenous sedation requirements

研究概览

简要总结

At the beginning of 2020, a global alert emerged which saturated intensive care units due to COVID-19 worldwide. This caused a need for mechanical ventilation due to atypical pneumonias that had a rapid evolution and respiratory failure; therefore the consumption of sedative agents in the intensive care units escalated. Suboptimal sedation in the intensive care unit, increases the adverse effects, costs, and morbidity. For the time being, they focus on the use of intravenous agents such as propofol or dexmedetomidine, which are associated with tolerance, withdrawal, delirium, and hemodynamic effects. Consequently, the need arises to maximize availability and effectiveness, which is why the intervention of the ANACONDA conservation device is carried out, which works with a heat and humidity exchange filter capable of administering isoflurane or sevoflurane with an efficiency of 90%.

详细描述

Analyze the difference in intravenous sedation requirements in patients with COVID-19. Patients who were assisted by a mechanical ventilator with sevoflurane versus conventional sedation.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
27 Years 至 85 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Adult patients with confirmed COVI-19 infection and assited with mechanical ventilation who entered critical care department.

排除标准

  • Tranfers to a different hospital.
  • Death within the first 24 hours of hospital stay.

结局指标

主要结局

Intravenous sedation requirements

时间窗: 7 days

Amount of intravenous sedation required

次要结局

  • Delirium(Hospital stay (up to 30 days))
  • Acute kidney injury(Hospital stay (up to 30 days))
  • VAP(Hospital stay (up to 30 days))

研究者

发起方
Hospital Español de Mexico
申办方类型
Other
责任方
Principal Investigator
主要研究者

Jose J Zaragoza, MD

Dr.

Hospital H+ Queretaro

研究点 (1)

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