Clinical study on the intervention of Taohong Tongluo Granule in microcirculation disorder of acute coronary syndrome

Phase 1

• Conditions: acute coronary syndrome

• Registration Number: ITMCTR2000003738
• Lead Sponsor: Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 20 February 2023

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

1. Patients with acute coronary syndrome who plan to undergo EMERGENCY PCI;
2. Those who meet the criteria for TCM syndrome differentiation of Blood stasis syndrome;
3. Between the ages of 18 and 75, regardless of gender;
4. Coronary angiography showed slow blood flow or no reflow;
5. Those who voluntarily sign the written informed consent.

Exclusion Criteria

1 Acute myocardial infarction complicated with serious complications, such as cardiac shock (conventional treatment cannot be corrected), complicated with mechanical complications;
2. Severe arrhythmia (such as rapid atrial fibrillation, ventricular tachycardia, high atrioventricular block, etc.);
3. Previous history of chronic heart failure or old myocardial infarction;
4. Patients with cardiomyopathy, rheumatic heart disease, severe valvular heart disease, cardiac tamponadosis, hypertensive emergency, pulmonary hypertension, severe chronic obstructive pulmonary disease or asthma in acute attack stage, severe infection, etc.;
Patients with severe primary diseases such as liver, kidney, endocrine, hematopoietic system or psychosis;
6. Patients with malignant tumor;
7. Allergic constitution, or allergic to multiple drugs and food, or known to be allergic to the ingredients of Compound Xuantong capsule;
Suspected or proven history of alcohol or drug abuse;
9. Pregnant or lactating women;
10. Recent history of cerebrovascular accident and major surgery and trauma.

Study & Design

• Study Type: Interventional study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Evaluation of microcirculation disturbance;

Secondary Outcome Measures

Name	Time	Method
BNP;Tni;TCM syndrome score;Quality of life score;HS-CRP;