Personalized Exercise Treatments for Older Veterans With Motoric Cognitive Risk Syndrome

Not Applicable

Not yet recruiting

• Conditions: Motoric Cognitive Risk Syndrome

• Registration Number: NCT06451874
• Lead Sponsor: VA Office of Research and Development

Brief Summary

This study will begin to evaluate personalized preventative dementia treatments for Veterans at risk for developing dementia. The investigators will target Veterans with Motoric Cognitive Risk syndrome (MCR), which is characterized by slow gait speed and cognitive concerns (e.g., problems with memory or concentrations).

Detailed Description

This study will involve therapeutic exercise treatments for Veterans with pre-clinical dementia syndrome. Participants will either participate in functional power training, music-based walking training, or a combination of both. The study will use a sequential multiple assignment, randomized trial (SMART) design. Successful completion of this study will lay the foundation for subsequent research trials, contributing to valuable evidence for personalized rehabilitation medicine for older Veterans.

Study Timeline

• Study First Submitted: 2024-06-04
• Study First Submitted QC: 2024-06-04
• Study First Posted: 2024-06-11
• Status Verified: 2025-06
• Last Update Submitted: 2025-06-05
• Last Update Posted: 2025-06-06
• Study Start: 2025-07-01
• Primary Completion: 2029-05-31
• Study Completion: 2029-12-31

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 54

Inclusion Criteria

1. Age 65
2. Receiving VA primary care
3. Community-dwelling
4. Motoric Cognitive Risky Syndrome i. Slow gait speed ii. Subjective cognitive concerns/complaints

Exclusion Criteria

1. Non-English speaking
2. Presence of a terminal disease
3. Major medical problem
4. Myocardial infarction or major surgery in the previous 3 months
5. Use of a walker
6. Dementia diagnostic
7. Mobility disability

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SEQUENTIAL

Primary Outcome Measures

Name	Time	Method
Enrollment/Baseline	Enrollment	Enrollment will be defined as the number of participants who were recruited and consented to the study.
Retention	Baseline to end of 12-week treatment	Retention will be defined as the number of participants who completed the 12-week exercise treatment.
Compliance	Baseline to end of 12-week treatment	Compliance will be defined by the proportion of completed treatment sessions.
Acceptability	End of 12-week treatment	Acceptability will be recorded by conducting interviews with participants who completed the 12-week exercise treatment.

Secondary Outcome Measures

Name	Time	Method
Gait Speed	Baseline to end of 12-week treatment	Change in gait speed will be assessed after 12-week exercise treatment.

Trial Locations

Locations (1)

VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA; 🇺🇸 Boston, Massachusetts, United States