Motoric Cognitive Risk Syndrome: Refining Treatment Strategies and Testing Feasibility to Personalize Treatment for Older Veterans
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 54
- 试验地点
- 2
- 主要终点
- Enrollment/Baseline
研究概览
简要总结
This study will begin to evaluate personalized preventative dementia treatments for Veterans at risk for developing dementia. The investigators will target Veterans with Motoric Cognitive Risk syndrome (MCR), which is characterized by slow gait speed and cognitive concerns (e.g., problems with memory or concentrations).
详细描述
This study will involve therapeutic exercise treatments for Veterans with pre-clinical dementia syndrome. Participants will either participate in functional power training, music-based walking training, or a combination of both. The study will use a sequential multiple assignment, randomized trial (SMART) design. Successful completion of this study will lay the foundation for subsequent research trials, contributing to valuable evidence for personalized rehabilitation medicine for older Veterans.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Sequential
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 65 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Receiving VA primary care
- •Community-dwelling
- •Motoric Cognitive Risky Syndrome i. Slow gait speed ii. Subjective cognitive concerns/complaints
排除标准
- •Non-English speaking
- •Presence of a terminal disease
- •Major medical problem
- •Myocardial infarction or major surgery in the previous 3 months
- •3-point walking pattern
- •Dementia diagnostic
- •Mobility disability
研究组 & 干预措施
Stage 1 Exercise Treatment
Participants will first be randomized to 6-week exercise treatment (FPT or MBDT)
干预措施: Functional Power Training (FPT) (Behavioral)
Stage 1 Exercise Treatment
Participants will first be randomized to 6-week exercise treatment (FPT or MBDT)
干预措施: Music-Based Digital Therapy (MBDT) (Behavioral)
Stage 2: Exercise Treatment
At 6-week, responsiveness (change in gait speed = 0.05 m/s) will be evaluated. Responders will continue with their assigned treatment and non-responders will be randomized to either continue assigned treatment or combined treatment for an additional 6 weeks.
干预措施: Functional Power Training (FPT) (Behavioral)
Stage 2: Exercise Treatment
At 6-week, responsiveness (change in gait speed = 0.05 m/s) will be evaluated. Responders will continue with their assigned treatment and non-responders will be randomized to either continue assigned treatment or combined treatment for an additional 6 weeks.
干预措施: Music-Based Digital Therapy (MBDT) (Behavioral)
Stage 2: Exercise Treatment
At 6-week, responsiveness (change in gait speed = 0.05 m/s) will be evaluated. Responders will continue with their assigned treatment and non-responders will be randomized to either continue assigned treatment or combined treatment for an additional 6 weeks.
干预措施: FPT + MBDT (Behavioral)
结局指标
主要结局
Enrollment/Baseline
时间窗: Enrollment
Enrollment will be defined as the number of participants who were recruited and consented to the study.
Retention
时间窗: Baseline to end of 12-week treatment
Retention will be defined as the number of participants who completed the 12-week exercise treatment.
Compliance
时间窗: Baseline to end of 12-week treatment
Compliance will be defined by the proportion of completed treatment sessions.
Acceptability
时间窗: End of 12-week treatment
Acceptability will be recorded by conducting interviews with participants who completed the 12-week exercise treatment.
次要结局
- Gait Speed(Baseline to end of 12-week treatment)