A Cross-sectional Observational Study to Evaluate the Role of Inferior Vena Cava Parameters to Assess Volume Load in Children with Nephrotic Syndrome.

Study Summary

Nephrotic syndrome is one of the common illnesses encountered in children, presently with oedema, proteinuria, hyperlipidemia.

History, physical findings, and laboratory tests have limited sensitivity and specificity to assess relative intravascular volume or volume responsiveness.

The clinical determination of relative intravascular volume and prediction of response to a volume intervention may be more difficult in hospitalized or critically ill patients because they are frequently not in a steady state, and may have mismatch between relative intravascular volume and blood pressure, or between intravascular and extravascular volume.

This study is aimed to understand the role of Inferior Vena Cava Parameters to assess the volume load in children with nephrotic syndrome. Children with nephrotic syndrome between 1 months and 12 yrs of age getting admitted to the Paediatric wards will be included in the study.

All routine blood and urine examination results will be included in the study. Inferior Vena Cava Parameters including Inferior Vena Cava Collapsibility and inferior vena cava collapsibility index will be noted from available records. The data will be collected with the help pf a predesigned proforma and analysed.

The sample size is calculated according to previous years data, average 60 patients of nephrotic syndrome get admitted every year. Since the duration of the study is 12 months and considering 10% attrition rate a sample size of 67 patients is considered

. The expected outcome from the study -

This study is expected to establish the role of Inferior Vena Cava Collapsibility and Inferior vena cava collapsibility index to assess the volume status in patients of nephrotic syndrome.

Thus, IVC collapsibility will prove to be simple non invasive and cost effective alternative to assess volume.