The Incorporation of Marine n-3 Polyunsaturated Fatty Acids in Pre- and Postmenopausal Women: a Randomized Double-Blinded Placebo-Controlled Clinical Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 92
- 试验地点
- 1
- 主要终点
- Content of marine n-PUFAs as percent of total content of fatty acids in adipose tissue and in platelets before and after intervention
研究概览
简要总结
The study is a randomised placebo controlled double-blinded clinical trial where a group of healthy pre- and postmenopausal women is randomised to the intake of fish oil capsules or placebo oil capsules for 12 weeks. Anthropometric measurements(weight, height,blood pressure) blood samples and adipose tissue biopsies will be taken in order to illustrate the effect of marine n-3 PUFAs (fish oil) on the concentration of circulating female hormones and to investigate what impact menopause might have on the ability to incorporate marine n-3 PUFAs into tissues.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •age 18-70 years old
- •healthy or well-treated chronic disease
排除标准
- •hormone treatment
- •foreseen compliance problem
- •fish oil consumers
研究组 & 干预措施
Premenopausal women-fishoil
干预措施: marine n-3 polyunsaturated fatty acids (Dietary Supplement)
Premenopausal-placebo
干预措施: thistle oil (Dietary Supplement)
Postmenopausal women-fishoil
干预措施: marine n-3 polyunsaturated fatty acids (Dietary Supplement)
Postmenopausal-placebo
干预措施: Thistle oil (Dietary Supplement)
结局指标
主要结局
Content of marine n-PUFAs as percent of total content of fatty acids in adipose tissue and in platelets before and after intervention
次要结局
- Measurement of oestrogen concentrations in blood before and after intervention