NCT05483257已完成不适用
Molecular Subtyping Based on Specific HLA-I Genotypes for Prognosis Evaluation in Resected Pancreatic Adenocarcinoma: A Retrospective Observational Cohort Study
BAIYONG SHEN1 个研究点 分布在 1 个国家目标入组 226 人开始时间: 2018年3月14日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 226
- 试验地点
- 1
- 主要终点
- Disease-free survival (DFS)
研究概览
简要总结
Pancreatic adenocarcinoma (PAAD) patients following surgeries are prone to relapse shortly, while it is not well understood by current biomarkers. Given the potential associations of human leukocyte antigen class I (HLA-I) genotype with oncogenic mutational profile and immunotherapy efficacy, we aimed to assess whether differential HLA-I genotype could predict the postoperative outcomes in resected PAAD patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 34 Years 至 84 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Radically resected pancreatic adenocarcinoma (stage I-III)
- •Resected tumor tissues and matched blood cells available
- •Signed informed consent
排除标准
- •Pancreatic cancer except pancreatic adenocarcinoma
- •Non-radical resection
结局指标
主要结局
Disease-free survival (DFS)
时间窗: 2 years
Comparison of DFS between patients with specific HLA-I genotypes or not
次要结局
未报告次要终点
研究者
BAIYONG SHEN
Professor
Ruijin Hospital
研究点 (1)
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